Initially obscure hepatotoxicity attributed to sildenafil

FHJ (Franciscus) Wolfhagen, HG (Hester) Vermeulen, Rob de Man, W Lesterhuis

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We describe a patient with a hepatotoxic reaction, presenting with general malaise, severe jaundice, and pruritus. This turned out to be caused by the, at first unrevealed, use of sildenafil. The injury seems to be hepatocanalicular, characterized by a hepatocellular liver test pattern, combined with extensive cholestasis on liver biopsy. One should bare in mind that the use of sildenafil may not be readily disclosed by the patient nor his doctor.
Original languageUndefined/Unknown
Pages (from-to)710-712
Number of pages3
JournalEuropean Journal of Gastroenterology & Hepatology
Issue number7
Publication statusPublished - 2008

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