Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Monika Šalandová; Ingmar A.J. van Hengel; Iulian Apachitei; Amir A. Zadpoor; Bram C.J. van der Eerden; Lidy E. Fratila-Apachitei

doi:10.1002/adhm.202002254

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Monika Šalandová, Ingmar A.J. van Hengel^*, Iulian Apachitei, Amir A. Zadpoor, Bram C.J. van der Eerden, Lidy E. Fratila-Apachitei^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Review article › Academic › peer-review

52 Citations (Scopus)

106 Downloads (Pure)

Abstract

Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.

Original language	English
Article number	2002254
Journal	Advanced healthcare materials
Volume	10
Issue number	12
Early online date	26 May 2021
DOIs	https://doi.org/10.1002/adhm.202002254
Publication status	Published - 23 Jun 2021

Bibliographical note

Funding Information:
B.C.J.v.d.E. and L.E.F.-A. contributed equally to this work. The research for this paper was financially supported by the Prosperos project, funded by the Interreg VA Flanders?The Netherlands program, CCI grant no. 2014TC16RFCB046. After initial online publication of this article, Table 8 was corrected on June 23, 2021, as the original version of this Table was missing its column headings. The editorial office apologizes for any inconvenience caused.

Funding Information:
B.C.J.v.d.E. and L.E.F.‐A. contributed equally to this work. The research for this paper was financially supported by the Prosperos project, funded by the Interreg VA Flanders—The Netherlands program, CCI grant no. 2014TC16RFCB046.

Publisher Copyright:
© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH

Access to Document

10.1002/adhm.202002254Licence: CC BY

Inorganic Agents for Enhanced Angiogenesis of Orthopedic BiomaterialsFinal published version, 1.14 MBLicence: CC BY

Cite this

@article{b25713d69cee4cf5b59e8d3014996c0b,

title = "Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials",

abstract = "Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.",

author = "Monika {\v S}alandov{\'a} and {van Hengel}, {Ingmar A.J.} and Iulian Apachitei and Zadpoor, {Amir A.} and {van der Eerden}, {Bram C.J.} and Fratila-Apachitei, {Lidy E.}",

note = "Funding Information: B.C.J.v.d.E. and L.E.F.-A. contributed equally to this work. The research for this paper was financially supported by the Prosperos project, funded by the Interreg VA Flanders?The Netherlands program, CCI grant no. 2014TC16RFCB046. After initial online publication of this article, Table 8 was corrected on June 23, 2021, as the original version of this Table was missing its column headings. The editorial office apologizes for any inconvenience caused. Funding Information: B.C.J.v.d.E. and L.E.F.‐A. contributed equally to this work. The research for this paper was financially supported by the Prosperos project, funded by the Interreg VA Flanders—The Netherlands program, CCI grant no. 2014TC16RFCB046. Publisher Copyright: {\textcopyright} 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH",

year = "2021",

month = jun,

day = "23",

doi = "10.1002/adhm.202002254",

language = "English",

volume = "10",

journal = "Advanced healthcare materials",

issn = "2192-2640",

publisher = "John Wiley & Sons Inc.",

number = "12",

}

TY - JOUR

T1 - Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

AU - Šalandová, Monika

AU - van Hengel, Ingmar A.J.

AU - Apachitei, Iulian

AU - Zadpoor, Amir A.

AU - van der Eerden, Bram C.J.

AU - Fratila-Apachitei, Lidy E.

N1 - Funding Information: B.C.J.v.d.E. and L.E.F.-A. contributed equally to this work. The research for this paper was financially supported by the Prosperos project, funded by the Interreg VA Flanders?The Netherlands program, CCI grant no. 2014TC16RFCB046. After initial online publication of this article, Table 8 was corrected on June 23, 2021, as the original version of this Table was missing its column headings. The editorial office apologizes for any inconvenience caused. Funding Information: B.C.J.v.d.E. and L.E.F.‐A. contributed equally to this work. The research for this paper was financially supported by the Prosperos project, funded by the Interreg VA Flanders—The Netherlands program, CCI grant no. 2014TC16RFCB046. Publisher Copyright: © 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH

PY - 2021/6/23

Y1 - 2021/6/23

N2 - Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.

AB - Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.

UR - http://www.scopus.com/inward/record.url?scp=85106433011&partnerID=8YFLogxK

U2 - 10.1002/adhm.202002254

DO - 10.1002/adhm.202002254

M3 - Review article

C2 - 34036754

AN - SCOPUS:85106433011

SN - 2192-2640

VL - 10

JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 12

M1 - 2002254

ER -

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this