Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?

E Vivier, H Spits, Tom Cupedo

Research output: Contribution to journalArticleAcademicpeer-review

143 Citations (Scopus)


Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed in utero in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing ROR gamma t) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.
Original languageUndefined/Unknown
Pages (from-to)229-234
Number of pages6
JournalNature Reviews Immunology
Issue number4
Publication statusPublished - 2009

Research programs

  • EMC MM-02-41-04

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