TY - JOUR
T1 - Interleukin-5 and eosinophil cationic protein in nasal lavages of rhinitis patients
AU - Garrelds, Ingrid M.
AU - De Graaf-in 't Veld, Tineke
AU - Nahori, Marie Anne
AU - Vargaftig, B. Boris
AU - van Wijk, Roy Gerth
AU - Zijlstra, Freek J.
N1 - Funding Information: This study was supported by Glaxo BV, Netherlands and by the Netherlands Asthma Foundation, Grant 32.92.74. Fluticasone propionate aqueous nasal spray was given by Glaxo.
PY - 1995/3/14
Y1 - 1995/3/14
N2 - The production of interleukin-5 and eosinophil cationic protein (ECP) in the nasal cavity was examined in 24 patients with rhinitis who were allergic to the house dust mite. During a double-blind placebo-controlled cross-over study, fluticasone propionate aqueous nasal spray (200 μg) was administered twice daily for 2 weeks. After four basal nasal lavages provocation with house dust mite extract was performed and nasal lavages were collected every hour for 9.5 h. Interleukin-5 was present in detectable amounts in nasal lavages from patients allergic to house dust mite. Nasal challenge with house dust mite extract caused immediate nasal symptoms and increased levels of interleukin-5. Between 3.5 and 8.5 h after the challenge symptoms recurred and interleukin-5 levels increased, reflecting a late phase reaction. Eosinophil cationic protein, a marker of activated eosinophils, was released between 6.5 and 9.5 h after challenge. Treatment with fluticasone propionate (as an aqueous nasal spray) significantly decreased the evoked interleukin-5 and ECP levels in the late phase reaction. This response was correlated with an improved symptom score. This could indicate that the number and activity of eosinophils are increased during the late phase allergic reaction, a response that is inhibited by corticosteroids.
AB - The production of interleukin-5 and eosinophil cationic protein (ECP) in the nasal cavity was examined in 24 patients with rhinitis who were allergic to the house dust mite. During a double-blind placebo-controlled cross-over study, fluticasone propionate aqueous nasal spray (200 μg) was administered twice daily for 2 weeks. After four basal nasal lavages provocation with house dust mite extract was performed and nasal lavages were collected every hour for 9.5 h. Interleukin-5 was present in detectable amounts in nasal lavages from patients allergic to house dust mite. Nasal challenge with house dust mite extract caused immediate nasal symptoms and increased levels of interleukin-5. Between 3.5 and 8.5 h after the challenge symptoms recurred and interleukin-5 levels increased, reflecting a late phase reaction. Eosinophil cationic protein, a marker of activated eosinophils, was released between 6.5 and 9.5 h after challenge. Treatment with fluticasone propionate (as an aqueous nasal spray) significantly decreased the evoked interleukin-5 and ECP levels in the late phase reaction. This response was correlated with an improved symptom score. This could indicate that the number and activity of eosinophils are increased during the late phase allergic reaction, a response that is inhibited by corticosteroids.
UR - http://www.scopus.com/inward/record.url?scp=0028938744&partnerID=8YFLogxK
UR - https://research.amanote.com/publication/EqKd4nMBKQvf0Bhi-sgC/interleukin-5-and-eosinophil-cationic-protein-in-nasal-lavages-of-rhinitis-patients
U2 - 10.1016/0014-2999(95)00049-Q
DO - 10.1016/0014-2999(95)00049-Q
M3 - Article
C2 - 7768298
AN - SCOPUS:0028938744
SN - 0014-2999
VL - 275
SP - 295
EP - 300
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -