Intestinal multicellular organoids to study colorectal cancer

Musa Idris, Maria M. Alves, Robert M.W. Hofstra, Maxime M. Mahe, Veerle Melotte*

*Corresponding author for this work

Research output: Contribution to journalReview articlePopular

15 Citations (Scopus)


Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.

Original languageEnglish
Article number188586
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Issue number2
Publication statusPublished - Dec 2021

Bibliographical note

Funding Information:
This work was funded by a Hestia – NWO grant ( VidW.1154.18.045 ) obtained by M. Idris and a VENI – NWO grant ( 016.186.124 ) awarded to Dr. V. Melotte.

Publisher Copyright:
© 2021 The Author(s)


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