Intestinal multicellular organoids to study colorectal cancer

Musa Idris; Maria M. Alves; Robert M.W. Hofstra; Maxime M. Mahe; Veerle Melotte

doi:10.1016/j.bbcan.2021.188586

Intestinal multicellular organoids to study colorectal cancer

Musa Idris
, Maria M. Alves
, Robert M.W. Hofstra
, Maxime M. Mahe
, Veerle Melotte^*

^*Corresponding author for this work

Clinical Genetics

Research output: Contribution to journal › Review article › Popular

26 Citations (Scopus)

Abstract

Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.

Original language	English
Article number	188586
Journal	Biochimica et Biophysica Acta - Reviews on Cancer
Volume	1876
Issue number	2
DOIs	https://doi.org/10.1016/j.bbcan.2021.188586
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
This work was funded by a Hestia – NWO grant ( VidW.1154.18.045 ) obtained by M. Idris and a VENI – NWO grant ( 016.186.124 ) awarded to Dr. V. Melotte.

Publisher Copyright:
© 2021 The Author(s)

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10.1016/j.bbcan.2021.188586

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title = "Intestinal multicellular organoids to study colorectal cancer",

abstract = "Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.",

author = "Musa Idris and Alves, \{Maria M.\} and Hofstra, \{Robert M.W.\} and Mahe, \{Maxime M.\} and Veerle Melotte",

note = "Funding Information: This work was funded by a Hestia – NWO grant ( VidW.1154.18.045 ) obtained by M. Idris and a VENI – NWO grant ( 016.186.124 ) awarded to Dr. V. Melotte. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

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doi = "10.1016/j.bbcan.2021.188586",

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AU - Idris, Musa

AU - Alves, Maria M.

AU - Hofstra, Robert M.W.

AU - Mahe, Maxime M.

AU - Melotte, Veerle

N1 - Funding Information: This work was funded by a Hestia – NWO grant ( VidW.1154.18.045 ) obtained by M. Idris and a VENI – NWO grant ( 016.186.124 ) awarded to Dr. V. Melotte. Publisher Copyright: © 2021 The Author(s)

PY - 2021/12

Y1 - 2021/12

N2 - Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.

AB - Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.

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U2 - 10.1016/j.bbcan.2021.188586

DO - 10.1016/j.bbcan.2021.188586

M3 - Review article

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AN - SCOPUS:85109429622

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VL - 1876

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

IS - 2

M1 - 188586

ER -

Intestinal multicellular organoids to study colorectal cancer

Abstract

Bibliographical note

UN SDGs

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