Intrahepatic cholangiocarcinoma in a low endemic area: rising incidence and improved survival

Carlijn Witjes, Henrike Kos, O (Otto) Visser, Esther Vries, J.N.M. IJzermans, Rob de Man, Jan Willem Coebergh, Kees Verhoef

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40 Citations (Scopus)


Background: To explore trends in the incidence and survival of patients with intrahepatic cholangiocarcinoma (ICC) an unselected population in Western Europe was studied. Methods: Between 1989 and 2009, all patients newly diagnosed with ICC were selected from the Netherlands Cancer Registry (n= 809). Trends in incidence, treatment and relative survival were calculated according to gender and age. Follow-up for vital status was complete until 1st January 2010. Results: The incidence rates of ICC increased significantly between 1999 and 2009, especially in the age group 4559 years [estimated annual percentage change +3.0%, 95% confidence interval (CI) 0.25.8]. In the other age groups ICC incidence remained stable. Patients diagnosed with Tumour Lymph Node Metastasis (TNM) stage I mainly underwent surgery (68%), and the majority of the patients with stage II, III and IV received best supportive care (73%). One-year relative survival for patients with ICC increased significantly from 24% in 19891994 to 28% in 20052009 (P= 0.03), and corresponding 3-year relative survival improved from 4% to 8% (P= 0.02). Three-month and 1-year relative survival for patients with ICC receiving surgery was 91% and 71%, respectively. Discussion: Between 1999 and 2009, the incidence of ICC rose, especially in the age group 4559 years, suggesting aetiological influences. Survival rates have improved during the study period.
Original languageUndefined/Unknown
Pages (from-to)777-781
Number of pages5
Issue number11
Publication statusPublished - 2012

Research programs

  • EMC MM-03-47-02-A
  • EMC MM-03-47-11
  • EMC MM-04-47-07
  • EMC NIHES-02-65-02

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