Intraplaque Hemorrhage, Fibrous Cap Status, and Microembolic Signals in Symptomatic Patients With Mild to Moderate Carotid Artery Stenosis The Plaque At RISK Study

MTB Truijman, AAJ de Rotte, R Aaslid, Anouk Dijk, J Steinbuch, MI Liem, FHBM Schreuder, Ton van der Steen, MJAP Daemen, RJ van Oostenbrugge, JE Wildberger, PJ Nederkoorn, J Hendrikse, Aad van der Lugt, ME Kooi, WH Mess

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Background and Purpose In patients with mild to moderate symptomatic carotid artery stenosis, intraplaque hemorrhage (IPH) and a thin/ruptured fibrous cap (FC) as evaluated with MRI, and the presence of microembolic signals (MESs) as detected with transcranial Doppler, are associated with an increased risk of a (recurrent) stroke. The objective of the present study is to determine whether the prevalence of MES differs in patients with and without IPH and thin/ruptured FC, and patients with only a thin/ruptured FC without IPH. Methods In this multicenter, diagnostic cohort study, patients with recent transient ischemic attack or minor stroke in the carotid territory and an ipsilateral mild to moderate carotid artery plaque were included. IPH and FC status were dichotomously scored. Analysis of transcranial Doppler data was done blinded for the MRI results. Differences between groups were analyzed with Fisher exact test. Results A total of 113 patients were included. Transcranial Doppler measurements were feasible in 105 patients (average recording time, 219 minutes). A total of 26 MESs were detected in 8 of 105 patients. In 44 of 105 plaques IPH was present. In 92 of 105 plaques FC status was assessable, 36 of these had a thin/ruptured FC. No significant difference in the prevalence of MES between patients with and without IPH (P=0.46) or with thick versus thin/ruptured FC (P=0.48) was found. Conclusions In patients with a symptomatic mild to moderate carotid artery stenosis, IPH and FC status are not associated with MES. This suggests that MRI and transcranial Doppler provide different information on plaque vulnerability. Clinical Trial Registration URL: Unique identifier: NCT01709045.
Original languageUndefined/Unknown
Pages (from-to)3423-3426
Number of pages4
Issue number11
Publication statusPublished - 2014

Research programs

  • EMC COEUR-09
  • EMC NIHES-03-30-01

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