Intrapulmonary Posaconazole Penetration at the Infection Site in an Immunosuppressed Murine Model of Invasive Pulmonary Aspergillosis Receiving Oral Prophylactic Regimens

Seyed Seyed Mousavi Tasieh, RJM Bruggemann, WJG Melchers, PE Verweij, Johan Mouton

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12 Citations (Scopus)


Adequate penetration to the infection/colonization site is crucial to attain optimal efficacy of posaconazole against Aspergillus fumigatus diseases. We evaluated posaconazole exposure in pulmonary epithelial lining fluid (ELF) in a murine model of invasive pulmonary aspergillosis. The posaconazole exposure (area under the plasma concentration-time curve from time zero to 24 h postinfusion [AUC(0-24)]) in ELF was 20% to 31% of that in plasma for total drug after the third dose, and the relationship between plasma and ELF exposure was linear (r(2) = 0.97, P = 0.016).
Original languageUndefined/Unknown
Pages (from-to)2964-2967
Number of pages4
JournalAntimicrobial Agents & Chemotherapy
Issue number5
Publication statusPublished - 2014

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