Intravascular optical coherence elastography

Tianshi Wang, Tom Pfeiffer, Ali Akyildiz, Heleen M.M. van Beusekom, Robert Huber, Antonius F.W. van der Steen, Gijs Van Soest*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Optical coherence elastography (OCE), a functional extension of optical coherence tomography (OCT), visualizes tissue strain to deduce the tissue’s biomechanical properties. In this study, we demonstrate intravascular OCE using a 1.1 mm motorized catheter and a 1.6 MHz Fourier domain mode-locked OCT system. We induced an intraluminal pressure change by varying the infusion rate from the proximal end of the catheter. We analysed the pixel-matched phase change between two different frames to yield the radial strain. Imaging experiments were carried out in a phantom and in human coronary arteries in vitro. At an imaging speed of 3019 frames/s, we were able to capture the dynamic strain. Stiff inclusions in the phantom and calcification in atherosclerotic plaques are associated with low strain values and can be distinguished from the surrounding soft material, which exhibits elevated strain. For the first time, circumferential intravascular OCE images are provided side by side with conventional OCT images, simultaneously mapping both the tissue structure and stiffness.

Original languageEnglish
Pages (from-to)5418-5433
Number of pages16
JournalBiomedical Optics Express
Volume13
Issue number10
DOIs
Publication statusPublished - 1 Oct 2022

Bibliographical note

Funding Information:
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (15940); ZonMw (104003006); Bundesministerium für Bildung und Forschung (13GW0227B); Deutsche Forschungsgemeinschaft (EXC 2167-390884018, HU1006/6 270871130); State of Schleswig-Holstein (Excellence Chair Program).

Publisher Copyright:
© 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

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