Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment

Tomohiko Teramoto; Fumiaki Ikeno; Hiromasa Otake; Jennifer K. Lyons; Heleen M.M. van Beusekom; William F. Fearon; Alan C. Yeung

doi:10.1253/circj.CJ-10-0189

Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment

Tomohiko Teramoto
, Fumiaki Ikeno^*
, Hiromasa Otake
, Jennifer K. Lyons
, Heleen M.M. van Beusekom
, William F. Fearon
, Alan C. Yeung

^*Corresponding author for this work

Cardiology

Stanford University

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

Abstract

Background: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than -PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.

Original language	English
Pages (from-to)	1257-1259
Number of pages	3
Journal	Circulation Journal
Volume	74
Issue number	6
DOIs	https://doi.org/10.1253/circj.CJ-10-0189
Publication status	Published - 2010

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title = "Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment",

abstract = "Background: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than -PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.",

author = "Tomohiko Teramoto and Fumiaki Ikeno and Hiromasa Otake and Lyons, \{Jennifer K.\} and \{van Beusekom\}, \{Heleen M.M.\} and Fearon, \{William F.\} and Yeung, \{Alan C.\}",

year = "2010",

doi = "10.1253/circj.CJ-10-0189",

language = "English",

volume = "74",

pages = "1257--1259",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "6",

}

TY - JOUR

T1 - Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment

AU - Teramoto, Tomohiko

AU - Ikeno, Fumiaki

AU - Otake, Hiromasa

AU - Lyons, Jennifer K.

AU - van Beusekom, Heleen M.M.

AU - Fearon, William F.

AU - Yeung, Alan C.

PY - 2010

Y1 - 2010

N2 - Background: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than -PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.

AB - Background: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than -PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.

UR - https://www.scopus.com/pages/publications/77953484204

U2 - 10.1253/circj.CJ-10-0189

DO - 10.1253/circj.CJ-10-0189

M3 - Article

C2 - 20453394

AN - SCOPUS:77953484204

SN - 1346-9843

VL - 74

SP - 1257

EP - 1259

JO - Circulation Journal

JF - Circulation Journal

IS - 6

ER -

Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment

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