Introduction of the donor centre virtual crossmatch in Eurotransplant

Sebastiaan Heidt*, Cynthia S M Kramer, Geert W Haasnoot, Alexander H Schmidt, Yvonne M Zoet, Frans H J Claas, Serge Vogelaar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

On 24 January 2023, Eurotransplant has introduced the virtual crossmatch for kidney and pancreas allocation as a better alternative for the physical Complement Dependent Cytotoxicity (CDC) crossmatches at the donor centre, which were associated with a longer cold ischaemia time and false positive reactions. For the time being, the physical CDC crossmatch at the recipient centre will remain in place as the final histocompatibility check. While Eurotransplant is certainly not the first organ allocation organisation to introduce virtual crossmatching, several novel aspects have been introduced, such as calculation of the virtual panel reactive antibody (vPRA) on 11 loci at the second-field level in addition to the serological broad and split level, electronic HLA typing data transmission using Histoimmunogenetics Markup Language (HML) file format, and the actual virtual crossmatch based on ambiguous, second-field HLA typing of the donor on all 11 loci. This short communication will focus on these novel aspects of the virtual crossmatch in Eurotransplant.

Original languageEnglish
Article numbere15653
JournalHLA
Volume104
Issue number2
DOIs
Publication statusPublished - Aug 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). HLA: Immune Response Genetics published by John Wiley & Sons Ltd.

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