TY - JOUR
T1 - Invasive aspergillosis mimicking metastatic lung cancer
AU - Vanfleteren, Michiel J.E.G.W.
AU - Dingemans, Anne Marie C.
AU - Surmont, Veerle F.
AU - Vermaelen, Karim Y.
AU - Postma, Alida A.
AU - Lashof, Astrid M.L.Oude
AU - Pitz, Cordula C.M.
AU - Hendriks, Lizza E.L.
N1 - Publisher Copyright:
© 2018 Vanfleteren, Dingemans, Surmont, Vermaelen, Postma, Oude Lashof, Pitz and Hendriks.
PY - 2018/6/5
Y1 - 2018/6/5
N2 - In a patient with a medical history of cancer, the most probable diagnosis of an 18FDG-avid pulmonary mass combined with intracranial abnormalities on brain imaging is metastasized cancer. However, sometimes a differential diagnosis with an infectious cause such as aspergillosis can be very challenging as both cancer and infection are sometimes difficult to distinguish. Pulmonary aspergillosis can present as an infectious pseudotumour with clinical and imaging characteristics mimicking lung cancer. Even in the presence of cerebral lesions, radiological appearance of abscesses can look like brain metastasis. These similarities can cause significant diagnostic difficulties with a subsequent therapeutic delay and a potential adverse outcome. Awareness of this infectious disease that can mimic lung cancer, even in an immunocompetent patient, is important. We report a case of a 65-year-old woman with pulmonary aspergillosis disseminated to the brain mimicking metastatic lung cancer.
AB - In a patient with a medical history of cancer, the most probable diagnosis of an 18FDG-avid pulmonary mass combined with intracranial abnormalities on brain imaging is metastasized cancer. However, sometimes a differential diagnosis with an infectious cause such as aspergillosis can be very challenging as both cancer and infection are sometimes difficult to distinguish. Pulmonary aspergillosis can present as an infectious pseudotumour with clinical and imaging characteristics mimicking lung cancer. Even in the presence of cerebral lesions, radiological appearance of abscesses can look like brain metastasis. These similarities can cause significant diagnostic difficulties with a subsequent therapeutic delay and a potential adverse outcome. Awareness of this infectious disease that can mimic lung cancer, even in an immunocompetent patient, is important. We report a case of a 65-year-old woman with pulmonary aspergillosis disseminated to the brain mimicking metastatic lung cancer.
UR - http://www.scopus.com/inward/record.url?scp=85048179636&partnerID=8YFLogxK
U2 - 10.3389/fonc.2018.00188
DO - 10.3389/fonc.2018.00188
M3 - Article
C2 - 29922593
AN - SCOPUS:85048179636
SN - 2234-943X
VL - 8
JO - Frontiers in Oncology
JF - Frontiers in Oncology
IS - JUN
M1 - 188
ER -
