Invited Brief Commentary on IUVS -2017-0216

John Vlot*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorProfessionalpeer-review

1 Citation (Scopus)


There is an ever-increasing focus in modern-day surgery on minimization of invasiveness and scars. Technical developments in instruments and insufflation equipment, but also advances in anesthesia have made possible even the most complex operations through single-site or even natural orifice surgery. The easily quantifiable benefit for the patient is in his or her scar. The disturbance of body homeostasis by anesthesia and surgery is much less easily quantified. The authors of this article describe an animal model using cytokines to measure the body's response to the trauma of surgery. Although the use of cytokines is a well-known method, the true implications of minimal access surgery cover a vastly broader spectrum. Pain, time-to-return-to-work and long-term effects on body-wall integrity cannot be measured in animals. However, the strength of an animal model lies in its reproducibility of conditions and surgical trauma, so comparisons between surgical techniques can actually be better assessed here than in the patient population. Using rats instead of larger animals greatly reduces the financial and logistic burden of experiments. There are however some caveats with the representability for laparoscopy of the proposed model. [...]
Original languageEnglish
Pages (from-to)61-62
Number of pages2
JournalJournal of Investigative Surgery
Issue number1
Early online date12 Mar 2018
Publication statusPublished - 2 Jan 2019


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