Iron deficiency after kidney transplantation

Joanna Sophia J. Vinke; Marith I. Francke; Michele F. Eisenga; Dennis A. Hesselink; Martin H. De Borst

doi:10.1093/ndt/gfaa123

Iron deficiency after kidney transplantation

Joanna Sophia J. Vinke, Marith I. Francke, Michele F. Eisenga, Dennis A. Hesselink, Martin H. De Borst^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.

Original language	English
Pages (from-to)	1976-1985
Number of pages	10
Journal	Nephrology Dialysis Transplantation
Volume	36
Issue number	11
Early online date	10 Sept 2020
DOIs	https://doi.org/10.1093/ndt/gfaa123
Publication status	Published - Nov 2021

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Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.

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title = "Iron deficiency after kidney transplantation",

abstract = "Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.",

author = "Vinke, {Joanna Sophia J.} and Francke, {Marith I.} and Eisenga, {Michele F.} and Hesselink, {Dennis A.} and {De Borst}, {Martin H.}",

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T1 - Iron deficiency after kidney transplantation

AU - Vinke, Joanna Sophia J.

AU - Francke, Marith I.

AU - Eisenga, Michele F.

AU - Hesselink, Dennis A.

AU - De Borst, Martin H.

PY - 2021/11

Y1 - 2021/11

N2 - Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.

AB - Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.

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DO - 10.1093/ndt/gfaa123

M3 - Review article

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AN - SCOPUS:85109144063

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VL - 36

SP - 1976

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Iron deficiency after kidney transplantation

Abstract

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