Is autonomic function associated with left ventricular systolic function in Chagas heart disease patients undergoing treatment for heart failure?

Lotte Raadschilders, MOD Rocha, L Sousa, Jan Nouwen, AL Ribeiro

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Introduction: The association between cardiac autonomic and left ventricular (LV) dysfunction in Chagas disease (ChD) is controversial. Methods: A standardized protocol that includes the Valsalva maneuver, a respiratory sinus arrhythmia (RSA) test, and an echocardiographic examination was used. Spearman correlation coefficients (rho) were used to investigate associations. Results: The study population consisted of 118 ChD patients undergoing current medical treatment, with an average LV ejection fraction of 51.4 +/- 2.6%. The LV ejection fraction and diastolic dimension were correlated with the Valsalva index (rho=0.358, p<0.001 and rho=-0.266, p=0.004, respectively) and the RSA (rho=0.391, p<0.001 and rho=-0.311, p<0.001, respectively). Conclusions: The impairment of LV function is directly associated with a reduction of cardiac autonomic modulation in ChD.
Original languageUndefined/Unknown
Pages (from-to)239-242
Number of pages4
JournalRevista da Sociedade Brasileira de Medicina Tropical
Issue number2
Publication statusPublished - 2014

Research programs

  • EMC MM-04-28-04

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