Is Fasting Good When One Is at Risk of Liver Cancer?

Iulia Minciuna*, Laurens A. van Kleef, Horia Stefanescu, Bogdan Procopet

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

4 Citations (Scopus)
128 Downloads (Pure)


Hepatocellular carcinoma (HCC), one of the leading causes of cancer-related deaths worldwide, is a multistep process that usually develops in the background of cirrhosis, but also in a non-cirrhotic state in patients with non-alcoholic fatty liver disease (NAFLD) or viral hepatis. Emerging evidence suggests that intermittent fasting can reduce the risk of cancer development and could improve response and tolerance to treatment through the metabolic and hormonal adaptations induced by the low energy availability that finally impairs cancer cells’ adaptability, survival and growth. The current review will outline the beneficial effects of fasting in NAFLD/NASH patients and the possible mechanisms that can prevent HCC development, including circadian clock re-synchronization, with a special focus on the possibility of applying this dietary intervention to cirrhotic patients.

Original languageEnglish
Article number5084
Issue number20
Publication statusPublished - 17 Oct 2022

Bibliographical note

Funding Information:
Grant endorsed by Romanian National Council for Scientific Research: project PN-III-P4-ID-PCE2020-1091.

Publisher Copyright:
© 2022 by the authors.


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