Isotopic Scintigraphy in Intrathecal Drug Delivery Failure: A Single-Institution Case Series

Elmar M. Delhaas*, Daniëlle M.E. van Assema, Alida C. Fröberg, Ben G.J.C. Zwezerijnen, Biswadjiet S. Harhangi, Sander P.G. Frankema, Frank J.P.M. Huygen, Aad van der Lugt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
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Background: The aim of this study was to assess the feasibility and diagnostic accuracy of an optimized 111Indium-diethylenetriamine-penta-acetic-acid single-photon-emission computed tomography (CT) (111In-DTPA SPECT-CT) examination in patients with suspected intrathecal drug delivery (ITDD) failure. 

Materials and Methods: Retrospective analysis of routinely collected observational data from a case series of patients in the setting of the academic Center for Pain Medicine, Departments of Radiology and Nuclear Medicine and Neurosurgery. Twenty-seven patients participated between January 2014 and January 2019. Thirty-six optimized examinations including standardized pump flow rate with additional SPECT-CT imaging and a stepwise standardized analysis were performed. A 10 mL mixture of medication and 20 MBq 111In-DTPA was injected into the pump reservoir. Planar and SPECT-CT images were acquired at 24, 48, and 72 hours (h) after injection and at 96 hours and/or seven days, if needed. All images were reassessed by the first two authors using an optimized procedure. 

Results and Conclusions: Twenty-two abnormalities were identified in 21 examinations, with these abnormalities consisting of leakage (n = 7), spinal catheter obstruction (n = 7), and cerebrospinal fluid flow obstruction (n = 8). Interventions (n = 19) confirmed the cause of ITDD failure. A false-positive finding at follow-up (n = 1) and a false-negative finding (n = 1) were encountered. Sensitivity was 95% (20/21) and the specificity 93% (14/15). A significant difference (p < 0.001) was found between the accuracy of the conventical and the optimized analysis. The optimized 111In-DTPA SPECT-CT examination is a powerful diagnostic tool for detecting the cause of ITDD failure.

Original languageEnglish
Pages (from-to)1190-1198
Number of pages9
Issue number7
Publication statusPublished - Oct 2021

Bibliographical note

Funding Information:
Source(s) of financial support: None.

Publisher Copyright:
© 2020 The Authors. Neuromodulation: Technology at the Neural Interface published by Wiley Periodicals LLC on behalf of International Neuromodulation Society.


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