Joint status of patients with nonsevere hemophilia A

Anne Fleur Zwagemaker, Fabienne R. Kloosterman, Robert Hemke, Samantha C. Gouw, Michiel Coppens, Lorenzo G.R. Romano, Marieke J.H.A. Kruip, Marjon H. Cnossen, Frank W.G. Leebeek, Barbara A. Hutten, Mario Maas, Karin Fijnvandraat*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: Joint bleeding in hemophilia may eventually lead to joint damage. In nonsevere hemophilia, joint bleeds occur infrequently. Currently, knowledge on the joint status of patients with nonsevere hemophilia using objective imaging is limited. Objective: To investigate the joint status in patients with nonsevere hemophilia A. Methods: This cross-sectional study included patients with nonsevere hemophilia A aged 24–55 years. Joint status was assessed by magnetic resonance imaging (MRI) of the elbows, knees, and ankles and International Prophylaxis Study Group (IPSG) scores were calculated. Lifetime joint bleeding history was collected from medical files. The contribution of factors to joint outcome was explored using multivariable linear regression analysis. Results: In total, 51 patients were included, of whom 19 (37%) had moderate and 32 (63%) had mild hemophilia. Patients had a median age of 43 years (interquartile range [IQR] 32–50), a median factor VIII activity of 10 IU/dl (IQR 4–16) and a median annual joint bleeding rate (AJBR) of 0.0 (IQR 0.0–0.2). Soft-tissue changes (IPSG subscore > 0) in the elbows, knees, and ankles were present in 19%, 71%, and 71% of patients, respectively. Osteochondral changes (IPSG subscore > 0) in the elbows, knees, and ankles were present in 0%, 20%, and 35% of patients, respectively. In 14% of bleed-free joints, hemosiderin depositions were observed. Age and AJBRs were most strongly associated with the IPSG score. Conclusion: This study demonstrates that a substantial proportion of adults with nonsevere hemophilia has joint changes on MRI despite low joint bleeding rates.

Original languageEnglish
Pages (from-to)1126-1137
Number of pages12
JournalJournal of Thrombosis and Haemostasis
Volume20
Issue number5
DOIs
Publication statusPublished - May 2022

Bibliographical note

ACKNOWLEDGMENTS
The authors thank Sandra van den Berg and Raschel van Luijk (Amsterdam UMC, Amsterdam, the Netherlands) for their technical support and help in conducting the MRI scans.
In addition, the authors thank Cees Nooij and Wypke de Boer for their training on assessment of the Haemophilia Joint Health Score.
This work was supported by grants from Novo Nordisk, CSL Behring (Prof. Heimburger Award 2016) and Bayer (Outcomes
Research Award of the Bayer Hemophilia Awards Program 2015). The funding sponsors had no role in the design and conduct of the
study; collection, management, analysis, and interpretation of the data; and preparation, review, and approval of the manuscript.

Publisher Copyright:
© 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.

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