Keep your macrophages fit for healthy aging

Jan Van den Bossche; Pieter J.M. Leenen

doi:10.1016/j.cmet.2021.02.004

Keep your macrophages fit for healthy aging

Jan Van den Bossche^*, Pieter J.M. Leenen

^*Corresponding author for this work

Immunology

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

42 Downloads (Pure)

Abstract

As age is the greatest risk factor for the development of most prevalent chronic diseases, there is an enormous interest in understanding the process of aging, with the hope of delaying or preventing age-related comorbidities. Along these lines, a recent study by Minhas et al. (2021) describes how aged macrophages downregulate glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), inducing an energy-deficient state that compromises macrophage function and supports maladaptive inflammation that together cause brain dysfunction.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	Cell Metabolism
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2021.02.004
Publication status	Published - 2 Mar 2021

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© 2021 Elsevier Inc.

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Keep your macrophages fit for healthy aging

Abstract

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