Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

Ellen Kilsdonk; Eline van Dulmen-den Broeder; LATER Study Group; Flora E. van Leeuwen; Marry M. van den Heuvel-Eibrink; Jacqueline J. Loonen; Helena J. van der Pal; Dorine Bresters; A. B. Versluys; Rob Pieters; Michael Hauptmann; Monique W.M. Jaspers; Sebastian J.C. Neggers; Martine F. Raphael; Wim J.E. Tissing; Leontine C.M. Kremer; Cécile M. Ronckers

doi:10.1080/07357907.2022.2034841

Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

Ellen Kilsdonk, Eline van Dulmen-den Broeder, LATER Study Group, Flora E. van Leeuwen, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Helena J. van der Pal, Dorine Bresters, A. B. Versluys, Rob Pieters, Michael Hauptmann, Monique W.M. Jaspers, Sebastian J.C. Neggers, Martine F. Raphael, Wim J.E. Tissing, Leontine C.M. Kremer^*, Cécile M. Ronckers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963–2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963–1979 vs. later (p-trend <0.001).

Original language	English
Pages (from-to)	413-424
Number of pages	12
Journal	Cancer Investigation
Volume	40
Issue number	5
Early online date	7 Mar 2022
DOIs	https://doi.org/10.1080/07357907.2022.2034841 https://doi.org/10.1080/07357907.2022.2034841
Publication status	Published - 2022

Bibliographical note

Funding Information:
This study was financially supported by the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration [Grant Agreement No. 257505; PanCareSurFup] and by Dutch Cancer Society [DCS grants DCOG.2011-5027 and UvA.2012-5517]. This work was also supported by KWF. We thank Ms. Ingeborg Lange, Ms. Bep Verkerk, and Mr. Dennis de Jongh for data-management and ICT support in various stages of this work, the local study data-managers in each of the seven -LATER centers and the DCOG trial bureau staff (Head J Lieverst) for their help in data collection. Furthermore, we thank the following (former) members of the LATER Study Group for their contributions: Lilian Batenburg, Huib Caron, Wil Dolsma, Gea Huizinga, Marloes Louwerens, Hanneke de Ridder, Lideke van der Steeg, Margreet Veening, and Andrica de Vries.

Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor and Francis Group, LLC.

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Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER CohortFinal published version, 2.22 MBLicence: CC BY-NC-ND

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Kilsdonk, E., van Dulmen-den Broeder, E., LATER Study Group, van Leeuwen, F. E., van den Heuvel-Eibrink, M. M., Loonen, J. J., van der Pal, H. J., Bresters, D., Versluys, A. B., Pieters, R., Hauptmann, M., Jaspers, M. W. M., Neggers, S. J. C., Raphael, M. F., Tissing, W. J. E., Kremer, L. C. M., & Ronckers, C. M. (2022). Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort. Cancer Investigation, 40(5), 413-424. https://doi.org/10.1080/07357907.2022.2034841, https://doi.org/10.1080/07357907.2022.2034841

@article{d5f834445c7c49f3b96b95f401e091e5,

title = "Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort",

abstract = "This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963–2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963–1979 vs. later (p-trend <0.001).",

author = "Ellen Kilsdonk and {van Dulmen-den Broeder}, Eline and {LATER Study Group} and {van Leeuwen}, {Flora E.} and {van den Heuvel-Eibrink}, {Marry M.} and Loonen, {Jacqueline J.} and {van der Pal}, {Helena J.} and Dorine Bresters and Versluys, {A. B.} and Rob Pieters and Michael Hauptmann and Jaspers, {Monique W.M.} and Neggers, {Sebastian J.C.} and Raphael, {Martine F.} and Tissing, {Wim J.E.} and Kremer, {Leontine C.M.} and Ronckers, {C{\'e}cile M.}",

note = "Funding Information: This study was financially supported by the European Union{\textquoteright}s Seventh Framework Programme for Research, Technological Development and Demonstration [Grant Agreement No. 257505; PanCareSurFup] and by Dutch Cancer Society [DCS grants DCOG.2011-5027 and UvA.2012-5517]. This work was also supported by KWF. We thank Ms. Ingeborg Lange, Ms. Bep Verkerk, and Mr. Dennis de Jongh for data-management and ICT support in various stages of this work, the local study data-managers in each of the seven -LATER centers and the DCOG trial bureau staff (Head J Lieverst) for their help in data collection. Furthermore, we thank the following (former) members of the LATER Study Group for their contributions: Lilian Batenburg, Huib Caron, Wil Dolsma, Gea Huizinga, Marloes Louwerens, Hanneke de Ridder, Lideke van der Steeg, Margreet Veening, and Andrica de Vries. Publisher Copyright: {\textcopyright} 2022 The Author(s). Published with license by Taylor and Francis Group, LLC.",

year = "2022",

doi = "10.1080/07357907.2022.2034841",

language = "English",

volume = "40",

pages = "413--424",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Taylor & Francis Group LLC Philadelphia",

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Kilsdonk, E, van Dulmen-den Broeder, E, LATER Study Group, van Leeuwen, FE, van den Heuvel-Eibrink, MM, Loonen, JJ, van der Pal, HJ, Bresters, D, Versluys, AB, Pieters, R, Hauptmann, M, Jaspers, MWM, Neggers, SJC, Raphael, MF, Tissing, WJE, Kremer, LCM & Ronckers, CM 2022, 'Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort', Cancer Investigation, vol. 40, no. 5, pp. 413-424. https://doi.org/10.1080/07357907.2022.2034841, https://doi.org/10.1080/07357907.2022.2034841

TY - JOUR

T1 - Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

AU - Kilsdonk, Ellen

AU - van Dulmen-den Broeder, Eline

AU - LATER Study Group

AU - van Leeuwen, Flora E.

AU - van den Heuvel-Eibrink, Marry M.

AU - Loonen, Jacqueline J.

AU - van der Pal, Helena J.

AU - Bresters, Dorine

AU - Versluys, A. B.

AU - Pieters, Rob

AU - Hauptmann, Michael

AU - Jaspers, Monique W.M.

AU - Neggers, Sebastian J.C.

AU - Raphael, Martine F.

AU - Tissing, Wim J.E.

AU - Kremer, Leontine C.M.

AU - Ronckers, Cécile M.

N1 - Funding Information: This study was financially supported by the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration [Grant Agreement No. 257505; PanCareSurFup] and by Dutch Cancer Society [DCS grants DCOG.2011-5027 and UvA.2012-5517]. This work was also supported by KWF. We thank Ms. Ingeborg Lange, Ms. Bep Verkerk, and Mr. Dennis de Jongh for data-management and ICT support in various stages of this work, the local study data-managers in each of the seven -LATER centers and the DCOG trial bureau staff (Head J Lieverst) for their help in data collection. Furthermore, we thank the following (former) members of the LATER Study Group for their contributions: Lilian Batenburg, Huib Caron, Wil Dolsma, Gea Huizinga, Marloes Louwerens, Hanneke de Ridder, Lideke van der Steeg, Margreet Veening, and Andrica de Vries. Publisher Copyright: © 2022 The Author(s). Published with license by Taylor and Francis Group, LLC.

PY - 2022

Y1 - 2022

N2 - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963–2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963–1979 vs. later (p-trend <0.001).

AB - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963–2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963–1979 vs. later (p-trend <0.001).

UR - http://www.scopus.com/inward/record.url?scp=85128800562&partnerID=8YFLogxK

U2 - 10.1080/07357907.2022.2034841

DO - 10.1080/07357907.2022.2034841

M3 - Article

C2 - 35175864

AN - SCOPUS:85128800562

SN - 0735-7907

VL - 40

SP - 413

EP - 424

JO - Cancer Investigation

JF - Cancer Investigation

IS - 5

ER -

Kilsdonk E, van Dulmen-den Broeder E, LATER Study Group, van Leeuwen FE, van den Heuvel-Eibrink MM, Loonen JJ et al. Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort. Cancer Investigation. 2022;40(5):413-424. Epub 2022 Mar 7. doi: 10.1080/07357907.2022.2034841, 10.1080/07357907.2022.2034841

Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

Abstract

Bibliographical note

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