Latent Acyclovir-Resistant Herpes Simplex Virus Type 1 in Trigeminal Ganglia of Immunocompetent Individuals

Monique Velzen, Freek Loenen, Roland Meesters, Miranda de Graaf, Lies Remeijer, Theo Luider, Ab Osterhaus, Georges Verjans

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33 Citations (Scopus)

Abstract

Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV(S)) and multiple phylogenetic-related minor ACV(S) and ACV(R) TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV(S) and ACV(R) latent HSV-1 in human TG.
Original languageUndefined/Unknown
Pages (from-to)1539-1543
Number of pages5
JournalJournal of Infectious Diseases
Volume205
Issue number10
DOIs
Publication statusPublished - 2012

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