Leadless pacing: a comprehensive review

  • Shmaila Saleem-Talib*
  • , Crispijn P.R. Hoevenaars
  • , Nadine Molitor
  • , Vincent J. van Driel
  • , Jeroen van der Heijden
  • , Alexander Breitenstein
  • , Harry van Wessel
  • , Mathijs S. van Schie
  • , Natasja M.S. de Groot
  • , Hemanth Ramanna
  • *Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

11 Citations (Scopus)
169 Downloads (Pure)

Abstract

Over the past decade, leadless pacing has undergone a rapid evolution, resulting in multiple leadless pacemaker (LPM) devices that offer advancements such as atrioventricular synchronized pacing in VDD mode, atrial stimulation, dual-chamber pacing, and longer battery longevity. Studies comparing LPMs with transvenous pacemakers (TVPMs) show a lower rate of device-related complications with LPMs. In the near future, LPMs could be combined with other devices such as non-transvenous implantable cardioverter-defibrillators to provide anti-tachycardia pacing or bradycardia pacing. Future prospectives for leadless cardiac resynchronization therapy and leadless conduction system pacing are being investigated. As LPMs continue to improve, their applications are anticipated to expand further improving patient outcome, promising a bright future for leadless pacing. In this review, the past, present, and future of leadless pacing are discussed with a focus on cutting-edge implantation techniques, clinical outcomes, and modern advancements of LPMs.

Original languageEnglish
Pages (from-to)1979-1990
Number of pages12
JournalEuropean Heart Journal
Volume46
Issue number21
Early online date19 Mar 2025
DOIs
Publication statusPublished - 1 Jun 2025

Bibliographical note

Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.

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