Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

P Houthuizen; LAFM Van Garsse; TT Poels; Peter de Jaegere; Robert van der Boon; BM Swinkels; JM v.d. Berg; F (Kley) van der Kley; MJ Schalij; Janneke Baan; R Cocchieri; GRG Brueren; AHM van Straten; P den Heijer; M Bentala; V van Ommen; J Kluin; PR Stella; MH Prins; JG Maessen; FW Prinzen

doi:10.1161/CIRCULATIONAHA.112.101055

Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

P Houthuizen, LAFM Van Garsse, TT Poels, Peter de Jaegere, Robert van der Boon, BM Swinkels, JM v.d. Berg, F (Kley) van der Kley, MJ Schalij, Janneke Baan, R Cocchieri, GRG Brueren, AHM van Straten, P den Heijer, M Bentala, V van Ommen, J Kluin, PR Stella, MH Prins, JG MaessenFW Prinzen

Research output: Contribution to journal › Article › Academic › peer-review

231 Citations (Scopus)

Abstract

Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interqu Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)

Original language	Undefined/Unknown
Pages (from-to)	720-728
Number of pages	9
Journal	Circulation
Volume	126
Issue number	6
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.112.101055
Publication status	Published - 2012

Access to Document

10.1161/CIRCULATIONAHA.112.101055

http://hdl.handle.net/1765/64863

Cite this

Houthuizen, P., Van Garsse, LAFM., Poels, TT., de Jaegere, P., van der Boon, R., Swinkels, BM., v.d. Berg, JM., van der Kley, F., Schalij, MJ., Baan, J., Cocchieri, R., Brueren, GRG., van Straten, AHM., den Heijer, P., Bentala, M., van Ommen, V., Kluin, J., Stella, PR., Prins, MH., ... Prinzen, FW. (2012). Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. Circulation, 126(6), 720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055

@article{66663c10e0f24fc1b9160e11fa2bfc2a,

title = "Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death",

abstract = "Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interqu Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)",

author = "P Houthuizen and {Van Garsse}, LAFM and TT Poels and {de Jaegere}, Peter and {van der Boon}, Robert and BM Swinkels and {v.d. Berg}, JM and {van der Kley}, {F (Kley)} and MJ Schalij and Janneke Baan and R Cocchieri and GRG Brueren and {van Straten}, AHM and {den Heijer}, P and M Bentala and {van Ommen}, V and J Kluin and PR Stella and MH Prins and JG Maessen and FW Prinzen",

year = "2012",

doi = "10.1161/CIRCULATIONAHA.112.101055",

language = "Undefined/Unknown",

volume = "126",

pages = "720--728",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

Houthuizen, P, Van Garsse, LAFM, Poels, TT, de Jaegere, P , van der Boon, R, Swinkels, BM, v.d. Berg, JM, van der Kley, F, Schalij, MJ, Baan, J, Cocchieri, R, Brueren, GRG, van Straten, AHM, den Heijer, P, Bentala, M, van Ommen, V, Kluin, J, Stella, PR, Prins, MH, Maessen, JG & Prinzen, FW 2012, 'Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death', Circulation, vol. 126, no. 6, pp. 720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055

TY - JOUR

T1 - Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

AU - Houthuizen, P

AU - Van Garsse, LAFM

AU - Poels, TT

AU - de Jaegere, Peter

AU - van der Boon, Robert

AU - Swinkels, BM

AU - v.d. Berg, JM

AU - van der Kley, F (Kley)

AU - Schalij, MJ

AU - Baan, Janneke

AU - Cocchieri, R

AU - Brueren, GRG

AU - van Straten, AHM

AU - den Heijer, P

AU - Bentala, M

AU - van Ommen, V

AU - Kluin, J

AU - Stella, PR

AU - Prins, MH

AU - Maessen, JG

AU - Prinzen, FW

PY - 2012

Y1 - 2012

N2 - Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interqu Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)

AB - Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interqu Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)

U2 - 10.1161/CIRCULATIONAHA.112.101055

DO - 10.1161/CIRCULATIONAHA.112.101055

M3 - Article

SN - 0009-7322

VL - 126

SP - 720

EP - 728

JO - Circulation

JF - Circulation

IS - 6

ER -