Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

P Houthuizen, LAFM Van Garsse, TT Poels, Peter de Jaegere, Robert van der Boon, BM Swinkels, JM v.d. Berg, F (Kley) van der Kley, MJ Schalij, Janneke Baan, R Cocchieri, GRG Brueren, AHM van Straten, P den Heijer, M Bentala, V van Ommen, J Kluin, PR Stella, MH Prins, JG MaessenFW Prinzen

Research output: Contribution to journalArticleAcademicpeer-review

235 Citations (Scopus)


Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interqu Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)
Original languageUndefined/Unknown
Pages (from-to)720-728
Number of pages9
Issue number6
Publication statusPublished - 2012

Research programs

  • EMC COEUR-09

Cite this