Leprosy indicators and diagnosis delay in Mogovolas, Meconta and Murrupula district of Nampula Province, Mozambique: A baseline survey

Abdoulaye Marega*, Thomas Hambridge, Yuki P. Stakteas, Anne Schoenmakers, Robin van Wijk, Liesbeth Mieras, Paulo Henrique Das Neves Martins Pires, Artur Manuel Muloliwa, Fernando Mitano, Jan Hendrik Richardus

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
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Abstract

Objectives Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The PEP4LEP project will compare two integrated skin-screening interventions combined with the distribution of a single dose of rifampicin as post exposure prophylaxis (SDR-PEP) for contacts of leprosy patients. To implement the study in Mozambique, it was necessary to assess recent epidemiological indicators of leprosy and to estimate case detection delay as a main outcome indicator at baseline. Methods This was a descriptive study to establish the trend of epidemiological indicators of leprosy in the Nampula province districts Murrupula, Meconta and Mogovolas in Mozambique, between 2015 and 2019; and to calculate the average delay to diagnose leprosy cases in these districts. The National Leprosy Control Programme was also described. For the estimation of the case detection delay, 81 recently diagnosed patients were interviewed. Results There were 939 new leprosy cases detected in the three districts from 2015 to 2019, with a high proportion of disability (17.0%). The mean diagnosis delay was 26.6 months (95% CI: 18.4–34.7), while the median was 17.0 months. Multibacillary cases had an average delay of 27.9 months (95% CI: 18.6–37.1), while those with grade 2 disability had an average delay of 47.8 months (95% CI: 15.4–80.2). Conclusion The long case detection delay and high grade 2 disability rates indicate that there is a need for active case finding and chemoprophylaxis with SDR-PEP to help interrupt the chain of Mycobacterium leprae transmission in Nampula province.

Original languageEnglish
Pages (from-to)197-208
Number of pages12
JournalLeprosy Review
Volume93
Issue number3
DOIs
Publication statusPublished - Sept 2022

Bibliographical note

Funding Information:
This project is part of the EDCTP2 programme supported by the European Union awarded to NLR/LM (grant number RIA2017NIM-1839-PEP4LEP), and the Leprosy Research Initiative (LRI; www.leprosyresearch.org) awarded to NLR/LM (grant number 707.19.58.). The funders had no role in study design, data collection or analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright: © The author(s).

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