Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase

Gijs R. Van Den Brink, Tom O'Toole, James C.H. Hardwick, Daniëlle E.M. Van Den Boogaardt, Henri H. Versteeg, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)

Abstract

The adipocyte-derived hormone leptin plays an important role as a relayer of nutritional status to several organ systems. Evidence is accumulating that leptin plays an important role in the adequate functioning and maintenance of the immune system. Here we show that leptin induces sustained phosphorylation of p38 MAP kinase in human peripheral blood mononuclear cells (PBMCs). We show furthermore that leptin induces two routes to phosphorylation of the 40S ribosomal protein S6, one is activation of the p90 ribosomal S6 kinase (RSK) via the MEK/p42/p44 MAP kinase pathway, the other is via activation of p70 S6 kinase. Thus, these results give new insight in the mechanism that underlies the immunomodulatory effects of leptin.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalMolecular Cell Biology Research Communications
Volume4
Issue number3
DOIs
Publication statusPublished - 2000
Externally publishedYes

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