Letter re: Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume

Kars C.J. Compagne; Adriaan C.G.M. van Es; Aad van der Lugt; Diederik W.J. Dippel

doi:10.1212/WNL.0000000000004712

Letter re: Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Demeestere et al. found no significant difference between the accuracy of Alberta Stroke Program Early CT Score (ASPECTS) or CT perfusion to identify ischemic stroke patients with a diffusion-weighted imaging (DWI) lesion of at least 70 mL, although CT perfusion with a core volume of 50 mL was more accurate than ASPECTS with an optimal cutoff value of less than 7.
Due to the retrospective observational design of this study,1 no treatment effect (i.e., clinical efficacy) could be assessed. Because of the wide inclusion period and limited number of patients (59 patients in 8.5 years),1 selection bias was very likely.
Another limitation of this study is that thrombolytic treatment was started between CT and MRI, and that last modality was performed within 100 minutes after CT perfusion.1 While thrombolytic agents can rapidly decrease the clot, delay between both imaging modalities and interim administration of thrombolysis could influence MRI diffusion lesion volume.
[...]

Original language	English
Pages (from-to)	2397-2398
Number of pages	2
Journal	Neurology
Volume	89
Issue number	23
DOIs	https://doi.org/10.1212/WNL.0000000000004712
Publication status	Published - 5 Dec 2017

Bibliographical note

Access to Document

10.1212/WNL.0000000000004712

Cite this

@article{133f103b0aee4154a94e1eeb4ad89790,

title = "Letter re: Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume",

abstract = "Demeestere et al. found no significant difference between the accuracy of Alberta Stroke Program Early CT Score (ASPECTS) or CT perfusion to identify ischemic stroke patients with a diffusion-weighted imaging (DWI) lesion of at least 70 mL, although CT perfusion with a core volume of 50 mL was more accurate than ASPECTS with an optimal cutoff value of less than 7. Due to the retrospective observational design of this study,1 no treatment effect (i.e., clinical efficacy) could be assessed. Because of the wide inclusion period and limited number of patients (59 patients in 8.5 years),1 selection bias was very likely. Another limitation of this study is that thrombolytic treatment was started between CT and MRI, and that last modality was performed within 100 minutes after CT perfusion.1 While thrombolytic agents can rapidly decrease the clot, delay between both imaging modalities and interim administration of thrombolysis could influence MRI diffusion lesion volume. [...]",

author = "Compagne, \{Kars C.J.\} and \{van Es\}, \{Adriaan C.G.M.\} and \{van der Lugt\}, Aad and Dippel, \{Diederik W.J.\}",

note = "{\textcopyright} 2017 American Academy of Neurology. ",

year = "2017",

month = dec,

day = "5",

doi = "10.1212/WNL.0000000000004712",

language = "English",

volume = "89",

pages = "2397--2398",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams \& Wilkins",

number = "23",

}

TY - JOUR

T1 - Letter re

T2 - Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume

AU - Compagne, Kars C.J.

AU - van Es, Adriaan C.G.M.

AU - van der Lugt, Aad

AU - Dippel, Diederik W.J.

PY - 2017/12/5

Y1 - 2017/12/5

N2 - Demeestere et al. found no significant difference between the accuracy of Alberta Stroke Program Early CT Score (ASPECTS) or CT perfusion to identify ischemic stroke patients with a diffusion-weighted imaging (DWI) lesion of at least 70 mL, although CT perfusion with a core volume of 50 mL was more accurate than ASPECTS with an optimal cutoff value of less than 7. Due to the retrospective observational design of this study,1 no treatment effect (i.e., clinical efficacy) could be assessed. Because of the wide inclusion period and limited number of patients (59 patients in 8.5 years),1 selection bias was very likely. Another limitation of this study is that thrombolytic treatment was started between CT and MRI, and that last modality was performed within 100 minutes after CT perfusion.1 While thrombolytic agents can rapidly decrease the clot, delay between both imaging modalities and interim administration of thrombolysis could influence MRI diffusion lesion volume. [...]

AB - Demeestere et al. found no significant difference between the accuracy of Alberta Stroke Program Early CT Score (ASPECTS) or CT perfusion to identify ischemic stroke patients with a diffusion-weighted imaging (DWI) lesion of at least 70 mL, although CT perfusion with a core volume of 50 mL was more accurate than ASPECTS with an optimal cutoff value of less than 7. Due to the retrospective observational design of this study,1 no treatment effect (i.e., clinical efficacy) could be assessed. Because of the wide inclusion period and limited number of patients (59 patients in 8.5 years),1 selection bias was very likely. Another limitation of this study is that thrombolytic treatment was started between CT and MRI, and that last modality was performed within 100 minutes after CT perfusion.1 While thrombolytic agents can rapidly decrease the clot, delay between both imaging modalities and interim administration of thrombolysis could influence MRI diffusion lesion volume. [...]

UR - https://www.scopus.com/pages/publications/85068852732

U2 - 10.1212/WNL.0000000000004712

DO - 10.1212/WNL.0000000000004712

M3 - Comment/Letter to the editor

C2 - 29203533

AN - SCOPUS:85068852732

SN - 0028-3878

VL - 89

SP - 2397

EP - 2398

JO - Neurology

JF - Neurology

IS - 23

ER -

Letter re: Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this