Leukocyte-facilitated entry of intracellular pathogens into the central nervous system

Douglas A. Drevets*, Pieter J.M. Leenen

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

44 Citations (Scopus)


Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
Pages (from-to)1609-1618
Number of pages10
JournalMicrobes and Infection
Issue number13
Publication statusPublished - Nov 2000

Bibliographical note

The authors thank R. Greenfield and T. Jelinek for their careful reading of the manuscript. This work was supported by grants NIH AI46651 and USDA 97-35204-5306 to D.A.D. and NATO CRG.971582 to D.A.D. and P.J.M.L.


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