Leukocyte-facilitated entry of intracellular pathogens into the central nervous system

Douglas A. Drevets; Pieter J.M. Leenen

doi:10.1016/S1286-4579(00)01317-4

Leukocyte-facilitated entry of intracellular pathogens into the central nervous system

Douglas A. Drevets^*, Pieter J.M. Leenen

^*Corresponding author for this work

Immunology

Research output: Contribution to journal › Review article › Academic › peer-review

44 Citations (Scopus)

Abstract

Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original language	English
Pages (from-to)	1609-1618
Number of pages	10
Journal	Microbes and Infection
Volume	2
Issue number	13
DOIs	https://doi.org/10.1016/S1286-4579(00)01317-4
Publication status	Published - Nov 2000

Bibliographical note

Acknowledgements:
The authors thank R. Greenfield and T. Jelinek for their careful reading of the manuscript. This work was supported by grants NIH AI46651 and USDA 97-35204-5306 to D.A.D. and NATO CRG.971582 to D.A.D. and P.J.M.L.

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10.1016/S1286-4579(00)01317-4

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title = "Leukocyte-facilitated entry of intracellular pathogens into the central nervous system",

abstract = "Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier. (C) 2000 Editions scientifiques et medicales Elsevier SAS.",

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note = "Acknowledgements: The authors thank R. Greenfield and T. Jelinek for their careful reading of the manuscript. This work was supported by grants NIH AI46651 and USDA 97-35204-5306 to D.A.D. and NATO CRG.971582 to D.A.D. and P.J.M.L.",

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AU - Leenen, Pieter J.M.

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N2 - Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

AB - Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

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JO - Microbes and Infection

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ER -

Leukocyte-facilitated entry of intracellular pathogens into the central nervous system

Abstract

Bibliographical note

UN SDGs

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