Abstract
Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
Original language | English |
---|---|
Pages (from-to) | 1609-1618 |
Number of pages | 10 |
Journal | Microbes and Infection |
Volume | 2 |
Issue number | 13 |
DOIs | |
Publication status | Published - Nov 2000 |
Bibliographical note
Acknowledgements:The authors thank R. Greenfield and T. Jelinek for their careful reading of the manuscript. This work was supported by grants NIH AI46651 and USDA 97-35204-5306 to D.A.D. and NATO CRG.971582 to D.A.D. and P.J.M.L.