Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs

martijs Jonker, JPM Melis, RV Kuiper, TV van der Hoeven, Paul Wackers, J Robinson, Bert van der Horst, Martijn Dollé, J Vijg, TM (Timo) Breit, Jan Hoeijmakers, H van Steeg

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Abstract

Summary Aging and age-related pathology is a result of a still incompletely understood intricate web of molecular and cellular processes. We present a C57BL/6J female mice in vivo aging study of five organs (liver, kidney, spleen, lung, and brain), in which we compare genome-wide gene expression profiles during chronological aging with pathological changes throughout the entire murine life span (13, 26, 52, 78, 104, and 130 weeks). Relating gene expression changes to chronological aging revealed many di
Original languageUndefined/Unknown
Pages (from-to)901-909
Number of pages9
JournalAging Cell
Volume12
Issue number5
DOIs
Publication statusPublished - 2013

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