Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial

Daniëlle E J Starreveld; Laurien A Daniels; Jacobien M Kieffer; Heiddis B Valdimarsdottir; Jessie de Geus; Mirthe Lanfermeijer; Eus J W van Someren; G Esther A Habers; Jos A Bosch; Cécile P M Janus; Dick Johan van Spronsen; Roel J de Weijer; Erik W A Marijt; Eva de Jongh; Josée M Zijlstra; Lara H Böhmer; Margreet Houmes; Marie José Kersten; Catharina M Korse; Huub H van Rossum; William H Redd; Susan K Lutgendorf; Sonia Ancoli-Israel; Flora E van Leeuwen; Eveline M A Bleiker

doi:10.3390/cancers13194948

Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial

Daniëlle E J Starreveld
, Laurien A Daniels
, Jacobien M Kieffer
, Heiddis B Valdimarsdottir
, Jessie de Geus
, Mirthe Lanfermeijer
, Eus J W van Someren
, G Esther A Habers
, Jos A Bosch
, Cécile P M Janus
, Dick Johan van Spronsen
, Roel J de Weijer
, Erik W A Marijt
, Eva de Jongh
, Josée M Zijlstra
, Lara H Böhmer
, Margreet Houmes
, Marie José Kersten
, Catharina M Korse
, Huub H van Rossum

William H Redd, Susan K Lutgendorf, Sonia Ancoli-Israel, Flora E van Leeuwen, Eveline M A Bleiker^*

^*Corresponding author for this work

Radiotherapy

Amsterdam UMC
Netherlands Cancer Institute
Icahn School of Medicine at Mount Sinai
Netherlands Institute for Neuroscience
Leiden University
Radboud University Medical Center
UMC Utrecht Cancer Center
Leiden University Medical Centre
Albert Schweitzer Ziekenhuis
Haga Ziekenhuis
Admiraal de Ruyter Hospital
University of Northern Iowa
University of California at San Diego

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

153 Downloads (Pure)

Abstract

PURPOSE: To evaluate the short- and long-term effects of light therapy on fatigue (primary outcome) and sleep quality, depression, anxiety, quality of life, and circadian rhythms (secondary outcomes) in survivors of (non-)Hodgkin lymphoma presenting with chronic cancer-related fatigue.

METHODS: We randomly assigned 166 survivors (mean survival 13 years) to a bright white light intervention (BWL) or dim white light comparison (DWL) group. Measurements were completed at baseline (T0), post-intervention (T1), at three (T2), and nine (T3) months follow-up. A mixed-effect modeling approach was used to compare linear and non-linear effects of time between groups.

RESULTS: There were no significant differences between BWL and DWL in the reduction in fatigue over time. Both BWL and DWL significantly (p < 0.001) improved fatigue levels during the intervention followed by a slight reduction in this effect during follow-up (EST0-T1 = -0.71; EST1-T3 = 0.15). Similar results were found for depression, sleep quality, and some aspects of quality of life. Light therapy had no effect on circadian rhythms.

CONCLUSIONS: BWL was not superior in reducing fatigue compared to DWL in HL and DLBCL survivors. Remarkably, the total sample showed clinically relevant and persistent improvements on fatigue not commonly seen in longitudinal observational studies in these survivors.

Original language	English
Article number	4948
Journal	Cancers
Volume	13
Issue number	19
DOIs	https://doi.org/10.3390/cancers13194948
Publication status	Published - 30 Sept 2021

Bibliographical note

Funding: This work was supported by the Dutch Cancer Society (Grant No. NKI 2015-7909).
The funder had no influence on study design, data collection, project management, data analysis,
interpretation, or manuscript preparation, review, or approval.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.3390/cancers13194948Licence: CC BY

cancers_13_04948_v2Final published version, 5.29 MBLicence: CC BY

Cite this

Starreveld, D. E. J., Daniels, L. A., Kieffer, J. M., Valdimarsdottir, H. B., de Geus, J., Lanfermeijer, M., van Someren, E. J. W., Habers, G. E. A., Bosch, J. A., Janus, C. P. M., van Spronsen, D. J., de Weijer, R. J., Marijt, E. W. A., de Jongh, E., Zijlstra, J. M., Böhmer, L. H., Houmes, M., Kersten, M. J., Korse, C. M., ... Bleiker, E. M. A. (2021). Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial. Cancers, 13(19), Article 4948. https://doi.org/10.3390/cancers13194948

@article{c7f4d91687774004a25d4d64ca3ac595,

title = "Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial",

abstract = "PURPOSE: To evaluate the short- and long-term effects of light therapy on fatigue (primary outcome) and sleep quality, depression, anxiety, quality of life, and circadian rhythms (secondary outcomes) in survivors of (non-)Hodgkin lymphoma presenting with chronic cancer-related fatigue.METHODS: We randomly assigned 166 survivors (mean survival 13 years) to a bright white light intervention (BWL) or dim white light comparison (DWL) group. Measurements were completed at baseline (T0), post-intervention (T1), at three (T2), and nine (T3) months follow-up. A mixed-effect modeling approach was used to compare linear and non-linear effects of time between groups.RESULTS: There were no significant differences between BWL and DWL in the reduction in fatigue over time. Both BWL and DWL significantly (p < 0.001) improved fatigue levels during the intervention followed by a slight reduction in this effect during follow-up (EST0-T1 = -0.71; EST1-T3 = 0.15). Similar results were found for depression, sleep quality, and some aspects of quality of life. Light therapy had no effect on circadian rhythms.CONCLUSIONS: BWL was not superior in reducing fatigue compared to DWL in HL and DLBCL survivors. Remarkably, the total sample showed clinically relevant and persistent improvements on fatigue not commonly seen in longitudinal observational studies in these survivors.",

author = "Starreveld, \{Dani{\"e}lle E J\} and Daniels, \{Laurien A\} and Kieffer, \{Jacobien M\} and Valdimarsdottir, \{Heiddis B\} and \{de Geus\}, Jessie and Mirthe Lanfermeijer and \{van Someren\}, \{Eus J W\} and Habers, \{G Esther A\} and Bosch, \{Jos A\} and Janus, \{C{\'e}cile P M\} and \{van Spronsen\}, \{Dick Johan\} and \{de Weijer\}, \{Roel J\} and Marijt, \{Erik W A\} and \{de Jongh\}, Eva and Zijlstra, \{Jos{\'e}e M\} and B{\"o}hmer, \{Lara H\} and Margreet Houmes and Kersten, \{Marie Jos{\'e}\} and Korse, \{Catharina M\} and \{van Rossum\}, \{Huub H\} and Redd, \{William H\} and Lutgendorf, \{Susan K\} and Sonia Ancoli-Israel and \{van Leeuwen\}, \{Flora E\} and Bleiker, \{Eveline M A\}",

note = "Funding: This work was supported by the Dutch Cancer Society (Grant No. NKI 2015-7909). The funder had no influence on study design, data collection, project management, data analysis, interpretation, or manuscript preparation, review, or approval.",

year = "2021",

month = sep,

day = "30",

doi = "10.3390/cancers13194948",

language = "English",

volume = "13",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "19",

}

Starreveld, DEJ, Daniels, LA, Kieffer, JM, Valdimarsdottir, HB, de Geus, J, Lanfermeijer, M, van Someren, EJW, Habers, GEA, Bosch, JA, Janus, CPM, van Spronsen, DJ, de Weijer, RJ, Marijt, EWA, de Jongh, E, Zijlstra, JM, Böhmer, LH, Houmes, M, Kersten, MJ, Korse, CM, van Rossum, HH, Redd, WH, Lutgendorf, SK, Ancoli-Israel, S, van Leeuwen, FE & Bleiker, EMA 2021, 'Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial', Cancers, vol. 13, no. 19, 4948. https://doi.org/10.3390/cancers13194948

TY - JOUR

T1 - Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors

T2 - Results of a Randomized Controlled Trial

AU - Starreveld, Daniëlle E J

AU - Daniels, Laurien A

AU - Kieffer, Jacobien M

AU - Valdimarsdottir, Heiddis B

AU - de Geus, Jessie

AU - Lanfermeijer, Mirthe

AU - van Someren, Eus J W

AU - Habers, G Esther A

AU - Bosch, Jos A

AU - Janus, Cécile P M

AU - van Spronsen, Dick Johan

AU - de Weijer, Roel J

AU - Marijt, Erik W A

AU - de Jongh, Eva

AU - Zijlstra, Josée M

AU - Böhmer, Lara H

AU - Houmes, Margreet

AU - Kersten, Marie José

AU - Korse, Catharina M

AU - van Rossum, Huub H

AU - Redd, William H

AU - Lutgendorf, Susan K

AU - Ancoli-Israel, Sonia

AU - van Leeuwen, Flora E

AU - Bleiker, Eveline M A

N1 - Funding: This work was supported by the Dutch Cancer Society (Grant No. NKI 2015-7909). The funder had no influence on study design, data collection, project management, data analysis, interpretation, or manuscript preparation, review, or approval.

PY - 2021/9/30

Y1 - 2021/9/30

N2 - PURPOSE: To evaluate the short- and long-term effects of light therapy on fatigue (primary outcome) and sleep quality, depression, anxiety, quality of life, and circadian rhythms (secondary outcomes) in survivors of (non-)Hodgkin lymphoma presenting with chronic cancer-related fatigue.METHODS: We randomly assigned 166 survivors (mean survival 13 years) to a bright white light intervention (BWL) or dim white light comparison (DWL) group. Measurements were completed at baseline (T0), post-intervention (T1), at three (T2), and nine (T3) months follow-up. A mixed-effect modeling approach was used to compare linear and non-linear effects of time between groups.RESULTS: There were no significant differences between BWL and DWL in the reduction in fatigue over time. Both BWL and DWL significantly (p < 0.001) improved fatigue levels during the intervention followed by a slight reduction in this effect during follow-up (EST0-T1 = -0.71; EST1-T3 = 0.15). Similar results were found for depression, sleep quality, and some aspects of quality of life. Light therapy had no effect on circadian rhythms.CONCLUSIONS: BWL was not superior in reducing fatigue compared to DWL in HL and DLBCL survivors. Remarkably, the total sample showed clinically relevant and persistent improvements on fatigue not commonly seen in longitudinal observational studies in these survivors.

AB - PURPOSE: To evaluate the short- and long-term effects of light therapy on fatigue (primary outcome) and sleep quality, depression, anxiety, quality of life, and circadian rhythms (secondary outcomes) in survivors of (non-)Hodgkin lymphoma presenting with chronic cancer-related fatigue.METHODS: We randomly assigned 166 survivors (mean survival 13 years) to a bright white light intervention (BWL) or dim white light comparison (DWL) group. Measurements were completed at baseline (T0), post-intervention (T1), at three (T2), and nine (T3) months follow-up. A mixed-effect modeling approach was used to compare linear and non-linear effects of time between groups.RESULTS: There were no significant differences between BWL and DWL in the reduction in fatigue over time. Both BWL and DWL significantly (p < 0.001) improved fatigue levels during the intervention followed by a slight reduction in this effect during follow-up (EST0-T1 = -0.71; EST1-T3 = 0.15). Similar results were found for depression, sleep quality, and some aspects of quality of life. Light therapy had no effect on circadian rhythms.CONCLUSIONS: BWL was not superior in reducing fatigue compared to DWL in HL and DLBCL survivors. Remarkably, the total sample showed clinically relevant and persistent improvements on fatigue not commonly seen in longitudinal observational studies in these survivors.

U2 - 10.3390/cancers13194948

DO - 10.3390/cancers13194948

M3 - Article

C2 - 34638428

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 19

M1 - 4948

ER -

Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial

Abstract

Bibliographical note

UN SDGs

Access to Document

Fingerprint

Cite this