Limited cross-border infections in patients newly diagnosed with HIV in Europe

Dineke Frentz, AMJ Wensing, J Albert, D Paraskevis, AB Abecasis, O Hamouda, LB Jorgensen, C Kucherer, D Struck, JC Schmit, B Asjo, C Balotta, D Beshkov, RJ Camacho, B Clotet, S Coughlan, S de Wit, A Griskevicius, Z Grossman, A HorbanT Kolupajeva, K Korn, LG Kostrikis, K Liitsola, M Linka, C Nielsen, D Otelea, R Paredes, M Poljak, E Puchhammer-Stockl, A Sonnerborg, D Stanekova, M Stanojevic, AM Vandamme, Charles Boucher, David van de Vijver

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Abstract

Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included. We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 Conclusions: Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.
Original languageUndefined/Unknown
JournalRetrovirology
Volume10
Issue number36
DOIs
Publication statusPublished - 2013

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