Limited cross-border infections in patients newly diagnosed with HIV in Europe

Dineke Frentz; AMJ Wensing; J Albert; D Paraskevis; AB Abecasis; O Hamouda; LB Jorgensen; C Kucherer; D Struck; JC Schmit; B Asjo; C Balotta; D Beshkov; RJ Camacho; B Clotet; S Coughlan; S de Wit; A Griskevicius; Z Grossman; A Horban; T Kolupajeva; K Korn; LG Kostrikis; K Liitsola; M Linka; C Nielsen; D Otelea; R Paredes; M Poljak; E Puchhammer-Stockl; A Sonnerborg; D Stanekova; M Stanojevic; AM Vandamme; Charles Boucher; David van de Vijver

doi:10.1186/1742-4690-10-36

Limited cross-border infections in patients newly diagnosed with HIV in Europe

Dineke Frentz, AMJ Wensing, J Albert, D Paraskevis, AB Abecasis, O Hamouda, LB Jorgensen, C Kucherer, D Struck, JC Schmit, B Asjo, C Balotta, D Beshkov, RJ Camacho, B Clotet, S Coughlan, S de Wit, A Griskevicius, Z Grossman, A HorbanT Kolupajeva, K Korn, LG Kostrikis, K Liitsola, M Linka, C Nielsen, D Otelea, R Paredes, M Poljak, E Puchhammer-Stockl, A Sonnerborg, D Stanekova, M Stanojevic, AM Vandamme, Charles Boucher, David van de Vijver

Virology

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Abstract

Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included. We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 Conclusions: Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.

Original language	Undefined/Unknown
Journal	Retrovirology
Volume	10
Issue number	36
DOIs	https://doi.org/10.1186/1742-4690-10-36
Publication status	Published - 2013

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EMC MM-04-27-01
EMC MM-04-28-04

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Cite this

Frentz, D., Wensing, AMJ., Albert, J., Paraskevis, D., Abecasis, AB., Hamouda, O., Jorgensen, LB., Kucherer, C., Struck, D., Schmit, JC., Asjo, B., Balotta, C., Beshkov, D., Camacho, RJ., Clotet, B., Coughlan, S., de Wit, S., Griskevicius, A., Grossman, Z., ... van de Vijver, D. (2013). Limited cross-border infections in patients newly diagnosed with HIV in Europe. Retrovirology, 10(36). https://doi.org/10.1186/1742-4690-10-36

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abstract = "Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included. We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 Conclusions: Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.",

author = "Dineke Frentz and AMJ Wensing and J Albert and D Paraskevis and AB Abecasis and O Hamouda and LB Jorgensen and C Kucherer and D Struck and JC Schmit and B Asjo and C Balotta and D Beshkov and RJ Camacho and B Clotet and S Coughlan and {de Wit}, S and A Griskevicius and Z Grossman and A Horban and T Kolupajeva and K Korn and LG Kostrikis and K Liitsola and M Linka and C Nielsen and D Otelea and R Paredes and M Poljak and E Puchhammer-Stockl and A Sonnerborg and D Stanekova and M Stanojevic and AM Vandamme and Charles Boucher and {van de Vijver}, David",

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Frentz, D, Wensing, AMJ, Albert, J, Paraskevis, D, Abecasis, AB, Hamouda, O, Jorgensen, LB, Kucherer, C, Struck, D, Schmit, JC, Asjo, B, Balotta, C, Beshkov, D, Camacho, RJ, Clotet, B, Coughlan, S, de Wit, S, Griskevicius, A, Grossman, Z, Horban, A, Kolupajeva, T, Korn, K, Kostrikis, LG, Liitsola, K, Linka, M, Nielsen, C, Otelea, D, Paredes, R, Poljak, M, Puchhammer-Stockl, E, Sonnerborg, A, Stanekova, D, Stanojevic, M, Vandamme, AM, Boucher, C & van de Vijver, D 2013, 'Limited cross-border infections in patients newly diagnosed with HIV in Europe', Retrovirology, vol. 10, no. 36. https://doi.org/10.1186/1742-4690-10-36

TY - JOUR

T1 - Limited cross-border infections in patients newly diagnosed with HIV in Europe

AU - Frentz, Dineke

AU - Wensing, AMJ

AU - Albert, J

AU - Paraskevis, D

AU - Abecasis, AB

AU - Hamouda, O

AU - Jorgensen, LB

AU - Kucherer, C

AU - Struck, D

AU - Schmit, JC

AU - Asjo, B

AU - Balotta, C

AU - Beshkov, D

AU - Camacho, RJ

AU - Clotet, B

AU - Coughlan, S

AU - de Wit, S

AU - Griskevicius, A

AU - Grossman, Z

AU - Horban, A

AU - Kolupajeva, T

AU - Korn, K

AU - Kostrikis, LG

AU - Liitsola, K

AU - Linka, M

AU - Nielsen, C

AU - Otelea, D

AU - Paredes, R

AU - Poljak, M

AU - Puchhammer-Stockl, E

AU - Sonnerborg, A

AU - Stanekova, D

AU - Stanojevic, M

AU - Vandamme, AM

AU - Boucher, Charles

AU - van de Vijver, David

PY - 2013

Y1 - 2013

N2 - Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included. We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 Conclusions: Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.

AB - Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included. We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 Conclusions: Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.

U2 - 10.1186/1742-4690-10-36

DO - 10.1186/1742-4690-10-36

M3 - Article

C2 - 23551870

SN - 1742-4690

VL - 10

JO - Retrovirology

JF - Retrovirology

IS - 36

ER -