Limited Size of the Fragile-x Site Shown By Fluorescence Insitu Hybridization

A J Verkerk, B H Eussen, J O Van Hemel, B A Oostra

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Cosmids, isolated from a 475 kb YAC that spans the fragile X region, and the YAC itself, were used for fluorescence in situ hybridization (FISH) on metaphase chromosomes from fragile X patients. Cosmid 22.3, containing most of the hybrid translocation breakpoints, shows in situ hybridization signals distal and proximal from the fragile X site. We propose that the size of the fragile site is limited to 20 kb.
Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume43
Issue number1-2
DOIs
Publication statusPublished - 15 Apr 1992

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