TY - GEN
T1 - Lipid distribution and viscosity of coated microbubbles
AU - Kooiman, Klazina
AU - Emmer, Marcia
AU - Kokhuis, Tom J.A.
AU - Bosch, Johan G.
AU - De Gruiter, H. Martijn
AU - Van Royen, Martin E.
AU - Van Cappellen, W. A.
AU - Houtsmuller, Adriaan B.
AU - Van Der Steen, Antonius F.W.
AU - De Jong, Nico
PY - 2010
Y1 - 2010
N2 - Ultrasound contrast agents consist of gas-filled coated microbubbles with diameters between 1 and 10 m. Within an ultrasound field, high differences in responses of similar sized microbubbles have been reported. Heterogeneous coating properties have been suggested to be the underlying cause. Until now, properties of this coating, like viscosity have been studied dynamically using a set-up of vibrating microbubbles in an ultrasound field. This study focuses on determining the viscosity of the coating for lipid-coated microbubbles in a static set-up. The viscosity of the coating was determined by measuring the mobility of a fluorescent lipid using Fluorescence Recovery After Photobleaching (FRAP). We found a surface shear viscosity of 8106 kg/s that was independent of the microbubble size. In addition, we found that the lipid distribution in the coating was heterogeneous and varied from microbubble to microbubble. In conclusion, this study shows that the static surface shear viscosity of the coating can be determined in an independent way which can now be used in microbubble dynamics models.
AB - Ultrasound contrast agents consist of gas-filled coated microbubbles with diameters between 1 and 10 m. Within an ultrasound field, high differences in responses of similar sized microbubbles have been reported. Heterogeneous coating properties have been suggested to be the underlying cause. Until now, properties of this coating, like viscosity have been studied dynamically using a set-up of vibrating microbubbles in an ultrasound field. This study focuses on determining the viscosity of the coating for lipid-coated microbubbles in a static set-up. The viscosity of the coating was determined by measuring the mobility of a fluorescent lipid using Fluorescence Recovery After Photobleaching (FRAP). We found a surface shear viscosity of 8106 kg/s that was independent of the microbubble size. In addition, we found that the lipid distribution in the coating was heterogeneous and varied from microbubble to microbubble. In conclusion, this study shows that the static surface shear viscosity of the coating can be determined in an independent way which can now be used in microbubble dynamics models.
UR - http://www.scopus.com/inward/record.url?scp=80054758462&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2010.5935903
DO - 10.1109/ULTSYM.2010.5935903
M3 - Conference proceeding
AN - SCOPUS:80054758462
SN - 9781457703829
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 900
EP - 903
BT - 2010 IEEE International Ultrasonics Symposium, IUS 2010
T2 - 2010 IEEE International Ultrasonics Symposium, IUS 2010
Y2 - 11 October 2010 through 14 October 2010
ER -