Lipid droplets and their interactions with other organelles in liver diseases

L (Liang) Wang, Jin Liu, Zhijiang Miao, Qiuwei Pan, Wanlu Cao

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Lipid droplets are cellular organelles used for lipid storage with a hydrophobic core of neutral lipids enclosed by a phospholipid monolayer. Besides presenting as giant single organelles in fat tissue, lipid droplets are also widely present as a multitude of small structures in hepatocytes, where they play key roles in health and disease of the liver. In addition to lipid storage, lipid droplets are also directly involved in lipid metabolism, membrane biosynthesis, cell signaling, inflammation, pathogen-host interaction and cancer development. In addition, they interact with other cellular organelles to regulate cellular biology. It is fair to say that the exact functions of lipid droplets in cellular physiology remain largely obscure. Thus prompted, here we aim to analyze the corpus of contemporary biomedical literature to create a framework as to how the role of lipid droplets in hepatocyte physiology and pathophysiology should be understood. The resulting framework should help understanding the interaction of lipid droplets with other organelles in important liver diseases, including fatty liver disease, viral hepatitis and liver cancer and direct further research directions.

Original languageEnglish
Article number105937
JournalInternational Journal of Biochemistry and Cell Biology
Publication statusPublished - Apr 2021

Bibliographical note

Funding Information:
This work is supported by the China Scholarship Council for funding PhD fellowships to L. Wang (No. 201708530248), J. Liu (No. 201606240079), Z. Miao (No. 201708530234 ). The authors thank Prof. Maikel Peppelenbosch (Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands) for critical revision of the article.

Publisher Copyright:
© 2021 The Author(s)

Research programs

  • EMC OR-01


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