Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review

Lakshmi Nayak, Chetan Bettegowda, Florian Scherer, Norbert Galldiks, Manmeet Ahluwalia, Alexander Baraniskin, Louisa von Baumgarten, Jacoline E.C. Bromberg, Andrés J.M. Ferreri, Christian Grommes, Khê Hoang-Xuan, Julia Kühn, James L. Rubenstein, Roberta Rudà, Michael Weller, Susan M. Chang, Martin J. van den Bent, Patrick Y. Wen, Riccardo Soffietti*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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BACKGROUND: The utility of liquid biopsies is well documented in several extracranial and intracranial (brain/leptomeningeal metastases, gliomas) tumors. METHODS: The RANO (Response Assessment in Neuro-Oncology) group has set up a multidisciplinary Task Force to critically review the role of blood and cerebrospinal fluid (CSF)-liquid biopsy in CNS lymphomas, with a main focus on primary central nervous system lymphomas (PCNSL). RESULTS: Several clinical applications are suggested: diagnosis of PCNSL in critical settings (elderly or frail patients, deep locations, and steroid responsiveness), definition of minimal residual disease, early indication of tumor response or relapse following treatments, and prediction of outcome. CONCLUSIONS: Thus far, no clinically validated circulating biomarkers for managing both primary and secondary CNS lymphomas exist. There is need of standardization of biofluid collection, choice of analytes, and type of technique to perform the molecular analysis. The various assays should be evaluated through well-organized central testing within clinical trials.

Original languageEnglish
Pages (from-to)993-1011
Number of pages19
Issue number6
Publication statusPublished - 1 Jun 2024

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact jou


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