Living myocardial slices: Advancing arrhythmia research

Jorik H. Amesz; Lu Zhang; Bian R. Everts; Natasja M.S. De Groot; Yannick J.H.J. Taverne

doi:10.3389/fphys.2023.1076261

Living myocardial slices: Advancing arrhythmia research

Jorik H. Amesz, Lu Zhang, Bian R. Everts, Natasja M.S. De Groot, Yannick J.H.J. Taverne^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Living myocardial slices (LMS) are ultrathin (150–400 µm) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation and easy control of living myocardial slices culture conditions. The aim of this review is to present the potential of this biomimetic interface using living myocardial slices in electrophysiological studies outlining advantages, disadvantages and future perspectives of the model. Furthermore, different electrophysiological techniques and their application on living myocardial slices will be discussed. The developments of living myocardial slices in electrophysiology research will hopefully lead to future breakthroughs in the understanding of cardiac arrhythmia mechanisms and the development of novel therapeutic options.

Original language	English
Article number	1076261
Journal	Frontiers in Physiology
Volume	14
DOIs	https://doi.org/10.3389/fphys.2023.1076261
Publication status	Published - 13 Jan 2023

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Publisher Copyright:
Copyright © 2023 Amesz, Zhang, Everts, De Groot and Taverne.

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Living myocardial slicesFinal published version, 1.24 MBLicence: CC BY

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title = "Living myocardial slices: Advancing arrhythmia research",

abstract = "Living myocardial slices (LMS) are ultrathin (150–400 µm) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation and easy control of living myocardial slices culture conditions. The aim of this review is to present the potential of this biomimetic interface using living myocardial slices in electrophysiological studies outlining advantages, disadvantages and future perspectives of the model. Furthermore, different electrophysiological techniques and their application on living myocardial slices will be discussed. The developments of living myocardial slices in electrophysiology research will hopefully lead to future breakthroughs in the understanding of cardiac arrhythmia mechanisms and the development of novel therapeutic options.",

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AU - Amesz, Jorik H.

AU - Zhang, Lu

AU - Everts, Bian R.

AU - De Groot, Natasja M.S.

AU - Taverne, Yannick J.H.J.

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Living myocardial slices: Advancing arrhythmia research

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