TY - JOUR
T1 - Local control in sinonasal malignant melanoma
T2 - Comparing conventional to hypofractionated radiotherapy
AU - Lansu, Jules
AU - Klop, Willem Martin
AU - Heemsbergen, Wilma
AU - Navran, Arash
AU - Al-Mamgani, Abrahim
AU - Langendijk, Johannes A.
AU - Kaanders, Johannes H.
AU - Terhaard, Chris
AU - Karakullukcu, Baris
AU - Hamming-Vrieze, Olga
N1 - Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Background: The purpose of this study was to analyze the effect of fractionation schedule on local control in postoperative radiotherapy (RT) for sinonasal malignant melanoma. Methods: Sixty-three patients who were treated with surgery and postoperative RT in 4 accredited head and neck cancer centers in the Netherlands between 1998 and 2013 were retrospectively studied. Outcomes with conventional fractionation (2-2.4 Gy per fraction; n = 27) were compared to hypofractionation (4-6 Gy per fraction; n = 36). The primary endpoint was local control and the secondary endpoint was toxicity. Results: Comparable local control rates were found after 2 and 5 years (63% vs 64% and 47% vs 53%; P =.73 for, respectively, conventional fractionation vs hypofractionation). Local recurrences were predominantly present ipsilateral (92%) and within the irradiated volume (88%). Late toxicity grade ≥ 3 was observed in 2 of 63 patients, 1 patient in both groups. Conclusion: Radiotherapy fractionation schedule did not influence the local control rate or the incidence of late toxicity in patients treated with surgery and RT for sinonasal malignant melanoma in this retrospective analysis. Due to this retrospective nature and the limited number of patients, strong recommendations cannot be made. Expected toxicity, patient convenience, and workload may be taken into account for the choice of fractionation schedule until conclusive evidence becomes available.
AB - Background: The purpose of this study was to analyze the effect of fractionation schedule on local control in postoperative radiotherapy (RT) for sinonasal malignant melanoma. Methods: Sixty-three patients who were treated with surgery and postoperative RT in 4 accredited head and neck cancer centers in the Netherlands between 1998 and 2013 were retrospectively studied. Outcomes with conventional fractionation (2-2.4 Gy per fraction; n = 27) were compared to hypofractionation (4-6 Gy per fraction; n = 36). The primary endpoint was local control and the secondary endpoint was toxicity. Results: Comparable local control rates were found after 2 and 5 years (63% vs 64% and 47% vs 53%; P =.73 for, respectively, conventional fractionation vs hypofractionation). Local recurrences were predominantly present ipsilateral (92%) and within the irradiated volume (88%). Late toxicity grade ≥ 3 was observed in 2 of 63 patients, 1 patient in both groups. Conclusion: Radiotherapy fractionation schedule did not influence the local control rate or the incidence of late toxicity in patients treated with surgery and RT for sinonasal malignant melanoma in this retrospective analysis. Due to this retrospective nature and the limited number of patients, strong recommendations cannot be made. Expected toxicity, patient convenience, and workload may be taken into account for the choice of fractionation schedule until conclusive evidence becomes available.
UR - http://www.scopus.com/inward/record.url?scp=85038228324&partnerID=8YFLogxK
U2 - 10.1002/hed.24979
DO - 10.1002/hed.24979
M3 - Article
C2 - 29044881
AN - SCOPUS:85038228324
SN - 1043-3074
VL - 40
SP - 86
EP - 93
JO - Head and Neck
JF - Head and Neck
IS - 1
ER -