Local control in sinonasal malignant melanoma: Comparing conventional to hypofractionated radiotherapy

Jules Lansu, Willem Martin Klop, Wilma Heemsbergen, Arash Navran, Abrahim Al-Mamgani, Johannes A. Langendijk, Johannes H. Kaanders, Chris Terhaard, Baris Karakullukcu, Olga Hamming-Vrieze*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)


Background: The purpose of this study was to analyze the effect of fractionation schedule on local control in postoperative radiotherapy (RT) for sinonasal malignant melanoma. Methods: Sixty-three patients who were treated with surgery and postoperative RT in 4 accredited head and neck cancer centers in the Netherlands between 1998 and 2013 were retrospectively studied. Outcomes with conventional fractionation (2-2.4 Gy per fraction; n = 27) were compared to hypofractionation (4-6 Gy per fraction; n = 36). The primary endpoint was local control and the secondary endpoint was toxicity. Results: Comparable local control rates were found after 2 and 5 years (63% vs 64% and 47% vs 53%; P =.73 for, respectively, conventional fractionation vs hypofractionation). Local recurrences were predominantly present ipsilateral (92%) and within the irradiated volume (88%). Late toxicity grade ≥ 3 was observed in 2 of 63 patients, 1 patient in both groups. Conclusion: Radiotherapy fractionation schedule did not influence the local control rate or the incidence of late toxicity in patients treated with surgery and RT for sinonasal malignant melanoma in this retrospective analysis. Due to this retrospective nature and the limited number of patients, strong recommendations cannot be made. Expected toxicity, patient convenience, and workload may be taken into account for the choice of fractionation schedule until conclusive evidence becomes available.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalHead and Neck
Issue number1
Publication statusPublished - Jan 2018
Externally publishedYes

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© 2017 Wiley Periodicals, Inc.


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