Local tumour control after radiofrequency or microwave ablation for colorectal liver metastases in relation to histopathological growth patterns

Mark Jan D. Vles; Diederik J. Höppener; Boris Galjart; Adriaan Moelker; Peter B. Vermeulen; Dirk J. Grünhagen; Cornelis Verhoef

doi:10.1016/j.hpb.2022.01.010

Local tumour control after radiofrequency or microwave ablation for colorectal liver metastases in relation to histopathological growth patterns

Mark Jan D. Vles, Diederik J. Höppener, Boris Galjart, Adriaan Moelker, Peter B. Vermeulen, Dirk J. Grünhagen, Cornelis Verhoef^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Regrowth after ablation is common, but predictive factors for local control are scarce. This study investigates whether histopathological growth patterns (HGP) can be used as a predictive biomarker for local control after ablation of colorectal liver metastases (CRLM).

METHODS: Patients who received simultaneous resection and ablation as first treatment for CRLM between 2000 and 2019 were considered eligible. HGPs were determined on resected CRLM according to international guidelines and were classified as desmoplastic or non-desmoplastic. As minimal inter-tumoural heterogeneity has been demonstrated, the HGP of resected and ablated CRLM were presumed to be identical. Local tumour progression (LTP) was assessed on postoperative surveillance imaging. Uni- and multivariable competing risk methods were used to compare LTP.

RESULTS: In total 221 patients with 443 ablated tumours were analysed. A desmoplastic HGP was found in 60 (27.1%) patients who had a total of 159 (34.7%) ablated lesions. Five-year LTP [95%CI] was significantly higher for ablated CRLM with a presumed non-desmoplastic HGP (37% [30-43] vs 24% [17-32], Gray's-test p = 0.014). On multivariable analysis, a non-desmoplastic HGP (adjusted HR [95%CI]; 1.55 [1.03-2.35]) was independently associated with higher LTP rates after ablation.

CONCLUSION: HGP is an independent predictor of local tumour progression following ablation of CRLM.

Original language	English
Pages (from-to)	1443-1452
Number of pages	10
Journal	HPB
Volume	24
Issue number	9
Early online date	23 Jan 2022
DOIs	https://doi.org/10.1016/j.hpb.2022.01.010
Publication status	Published - 1 Sept 2022

Bibliographical note

Funding
This research did not receive any grant from funding agencies in the public,
commercial, or not-for-profit agencies.

Publisher Copyright:
© 2022 The Authors

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Local tumour control after radiofrequency or microwave ablation for colorectal liver metastases in relation to histopathological growth patternsFinal published version, 949 KBLicence: CC BY

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@article{daba224dadf94d21a95e8e2c56f5b3fe,

title = "Local tumour control after radiofrequency or microwave ablation for colorectal liver metastases in relation to histopathological growth patterns",

abstract = "BACKGROUND: Regrowth after ablation is common, but predictive factors for local control are scarce. This study investigates whether histopathological growth patterns (HGP) can be used as a predictive biomarker for local control after ablation of colorectal liver metastases (CRLM).METHODS: Patients who received simultaneous resection and ablation as first treatment for CRLM between 2000 and 2019 were considered eligible. HGPs were determined on resected CRLM according to international guidelines and were classified as desmoplastic or non-desmoplastic. As minimal inter-tumoural heterogeneity has been demonstrated, the HGP of resected and ablated CRLM were presumed to be identical. Local tumour progression (LTP) was assessed on postoperative surveillance imaging. Uni- and multivariable competing risk methods were used to compare LTP.RESULTS: In total 221 patients with 443 ablated tumours were analysed. A desmoplastic HGP was found in 60 (27.1%) patients who had a total of 159 (34.7%) ablated lesions. Five-year LTP [95%CI] was significantly higher for ablated CRLM with a presumed non-desmoplastic HGP (37% [30-43] vs 24% [17-32], Gray's-test p = 0.014). On multivariable analysis, a non-desmoplastic HGP (adjusted HR [95%CI]; 1.55 [1.03-2.35]) was independently associated with higher LTP rates after ablation.CONCLUSION: HGP is an independent predictor of local tumour progression following ablation of CRLM.",

author = "Vles, {Mark Jan D.} and H{\"o}ppener, {Diederik J.} and Boris Galjart and Adriaan Moelker and Vermeulen, {Peter B.} and Gr{\"u}nhagen, {Dirk J.} and Cornelis Verhoef",

note = "Funding This research did not receive any grant from funding agencies in the public, commercial, or not-for-profit agencies. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = sep,

day = "1",

doi = "10.1016/j.hpb.2022.01.010",

language = "English",

volume = "24",

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journal = "HPB",

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number = "9",

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T1 - Local tumour control after radiofrequency or microwave ablation for colorectal liver metastases in relation to histopathological growth patterns

AU - Vles, Mark Jan D.

AU - Höppener, Diederik J.

AU - Galjart, Boris

AU - Moelker, Adriaan

AU - Vermeulen, Peter B.

AU - Grünhagen, Dirk J.

AU - Verhoef, Cornelis

PY - 2022/9/1

Y1 - 2022/9/1

N2 - BACKGROUND: Regrowth after ablation is common, but predictive factors for local control are scarce. This study investigates whether histopathological growth patterns (HGP) can be used as a predictive biomarker for local control after ablation of colorectal liver metastases (CRLM).METHODS: Patients who received simultaneous resection and ablation as first treatment for CRLM between 2000 and 2019 were considered eligible. HGPs were determined on resected CRLM according to international guidelines and were classified as desmoplastic or non-desmoplastic. As minimal inter-tumoural heterogeneity has been demonstrated, the HGP of resected and ablated CRLM were presumed to be identical. Local tumour progression (LTP) was assessed on postoperative surveillance imaging. Uni- and multivariable competing risk methods were used to compare LTP.RESULTS: In total 221 patients with 443 ablated tumours were analysed. A desmoplastic HGP was found in 60 (27.1%) patients who had a total of 159 (34.7%) ablated lesions. Five-year LTP [95%CI] was significantly higher for ablated CRLM with a presumed non-desmoplastic HGP (37% [30-43] vs 24% [17-32], Gray's-test p = 0.014). On multivariable analysis, a non-desmoplastic HGP (adjusted HR [95%CI]; 1.55 [1.03-2.35]) was independently associated with higher LTP rates after ablation.CONCLUSION: HGP is an independent predictor of local tumour progression following ablation of CRLM.

AB - BACKGROUND: Regrowth after ablation is common, but predictive factors for local control are scarce. This study investigates whether histopathological growth patterns (HGP) can be used as a predictive biomarker for local control after ablation of colorectal liver metastases (CRLM).METHODS: Patients who received simultaneous resection and ablation as first treatment for CRLM between 2000 and 2019 were considered eligible. HGPs were determined on resected CRLM according to international guidelines and were classified as desmoplastic or non-desmoplastic. As minimal inter-tumoural heterogeneity has been demonstrated, the HGP of resected and ablated CRLM were presumed to be identical. Local tumour progression (LTP) was assessed on postoperative surveillance imaging. Uni- and multivariable competing risk methods were used to compare LTP.RESULTS: In total 221 patients with 443 ablated tumours were analysed. A desmoplastic HGP was found in 60 (27.1%) patients who had a total of 159 (34.7%) ablated lesions. Five-year LTP [95%CI] was significantly higher for ablated CRLM with a presumed non-desmoplastic HGP (37% [30-43] vs 24% [17-32], Gray's-test p = 0.014). On multivariable analysis, a non-desmoplastic HGP (adjusted HR [95%CI]; 1.55 [1.03-2.35]) was independently associated with higher LTP rates after ablation.CONCLUSION: HGP is an independent predictor of local tumour progression following ablation of CRLM.

UR - http://www.scopus.com/inward/record.url?scp=85124189794&partnerID=8YFLogxK

U2 - 10.1016/j.hpb.2022.01.010

DO - 10.1016/j.hpb.2022.01.010

M3 - Article

C2 - 35144863

AN - SCOPUS:85124189794

SN - 1365-182X

VL - 24

SP - 1443

EP - 1452

JO - HPB

JF - HPB

IS - 9

ER -

Local tumour control after radiofrequency or microwave ablation for colorectal liver metastases in relation to histopathological growth patterns

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