Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk; G Zhai; Joyce van Meurs; Michael Verbiest; Jenny Visser; Karol Estrada Gil; Fernando Rivadeneira; FM Williams; L Cherkas; P Deloukas; N Soranzo; JJ Keyzer; VJM Pop; P Lips; CEI (Corinne) Lebrun; YT van der Schouw; DE (Diederick) Grobbee; JCM Witteman; Bert Hofman; Huib Pols; Joop Laven; TD Spector; André Uitterlinden

doi:10.1038/ng.387

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk, G Zhai, Joyce van Meurs, Michael Verbiest, Jenny Visser, Karol Estrada Gil, Fernando Rivadeneira, FM Williams, L Cherkas, P Deloukas, N Soranzo, JJ Keyzer, VJM Pop, P Lips, CEI (Corinne) Lebrun, YT van der Schouw, DE (Diederick) Grobbee, JCM Witteman, Bert Hofman, Huib PolsJoop Laven, TD Spector, André Uitterlinden

Research output: Contribution to journal › Article › Academic › peer-review

143 Citations (Scopus)

Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

Original language	Undefined/Unknown
Pages (from-to)	645-647
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	6
DOIs	https://doi.org/10.1038/ng.387
Publication status	Published - 2009

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Access to Document

10.1038/ng.387

http://hdl.handle.net/1765/24579

Cite this

Stolk, L., Zhai, G., van Meurs, J., Verbiest, M., Visser, J., Estrada Gil, K., Rivadeneira, F., Williams, FM., Cherkas, L., Deloukas, P., Soranzo, N., Keyzer, JJ., Pop, VJM., Lips, P., Lebrun, CEI., van der Schouw, YT., Grobbee, DE., Witteman, JCM., Hofman, B., ... Uitterlinden, A. (2009). Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nature Genetics, 41(6), 645-647. https://doi.org/10.1038/ng.387

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title = "Loci at chromosomes 13, 19 and 20 influence age at natural menopause",

abstract = "We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.",

author = "Lisette Stolk and G Zhai and {van Meurs}, Joyce and Michael Verbiest and Jenny Visser and {Estrada Gil}, Karol and Fernando Rivadeneira and FM Williams and L Cherkas and P Deloukas and N Soranzo and JJ Keyzer and VJM Pop and P Lips and Lebrun, {CEI (Corinne)} and {van der Schouw}, YT and Grobbee, {DE (Diederick)} and JCM Witteman and Bert Hofman and Huib Pols and Joop Laven and TD Spector and Andr{\'e} Uitterlinden",

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Stolk, L, Zhai, G, van Meurs, J , Verbiest, M , Visser, J, Estrada Gil, K, Rivadeneira, F, Williams, FM, Cherkas, L, Deloukas, P, Soranzo, N, Keyzer, JJ, Pop, VJM, Lips, P, Lebrun, CEI, van der Schouw, YT, Grobbee, DE, Witteman, JCM, Hofman, B, Pols, H, Laven, J, Spector, TD & Uitterlinden, A 2009, 'Loci at chromosomes 13, 19 and 20 influence age at natural menopause', Nature Genetics, vol. 41, no. 6, pp. 645-647. https://doi.org/10.1038/ng.387

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T1 - Loci at chromosomes 13, 19 and 20 influence age at natural menopause

AU - Stolk, Lisette

AU - Zhai, G

AU - van Meurs, Joyce

AU - Verbiest, Michael

AU - Visser, Jenny

AU - Estrada Gil, Karol

AU - Rivadeneira, Fernando

AU - Williams, FM

AU - Cherkas, L

AU - Deloukas, P

AU - Soranzo, N

AU - Keyzer, JJ

AU - Pop, VJM

AU - Lips, P

AU - Lebrun, CEI (Corinne)

AU - van der Schouw, YT

AU - Grobbee, DE (Diederick)

AU - Witteman, JCM

AU - Hofman, Bert

AU - Pols, Huib

AU - Laven, Joop

AU - Spector, TD

AU - Uitterlinden, André

PY - 2009

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AB - We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

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