Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk, G Zhai, Joyce van Meurs, Michael Verbiest, Jenny Visser, Karol Estrada Gil, Fernando Rivadeneira, FM Williams, L Cherkas, P Deloukas, N Soranzo, JJ Keyzer, VJM Pop, P Lips, CEI (Corinne) Lebrun, YT van der Schouw, DE (Diederick) Grobbee, JCM Witteman, Bert Hofman, Huib PolsJoop Laven, TD Spector, André Uitterlinden

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.
Original languageUndefined/Unknown
Pages (from-to)645-647
Number of pages3
JournalNature Genetics
Volume41
Issue number6
DOIs
Publication statusPublished - 2009

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