Long-range gene regulation and novel therapeutic applications

anita Heuvel, Ralph Stadhouders, C Andrieu-Soler, Frank Grosveld, E Soler

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.
Original languageUndefined/Unknown
Pages (from-to)1521-1525
Number of pages5
Issue number10
Publication statusPublished - 2015

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