Long-range gene regulation and novel therapeutic applications

anita Heuvel; Ralph Stadhouders; C Andrieu-Soler; Frank Grosveld; E Soler

doi:10.1182/blood-2014-11-567925

Long-range gene regulation and novel therapeutic applications

anita Heuvel, Ralph Stadhouders, C Andrieu-Soler, Frank Grosveld, E Soler

Cell biology

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.

Original language	Undefined/Unknown
Pages (from-to)	1521-1525
Number of pages	5
Journal	Blood
Volume	125
Issue number	10
DOIs	https://doi.org/10.1182/blood-2014-11-567925
Publication status	Published - 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1182/blood-2014-11-567925

Cite this

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abstract = "An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.",

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AU - Andrieu-Soler, C

AU - Grosveld, Frank

AU - Soler, E

PY - 2015

Y1 - 2015

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AB - An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.

U2 - 10.1182/blood-2014-11-567925

DO - 10.1182/blood-2014-11-567925

M3 - Article

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VL - 125

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JO - Blood

JF - Blood

IS - 10

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