TY - JOUR
T1 - Long-term cardiometabolic health in people born after assisted reproductive technology
T2 - a multi-cohort analysis
AU - Elhakeem, Ahmed
AU - Taylor, Amy E.
AU - Inskip, Hazel M.
AU - Huang, Jonathan Y.
AU - Mansell, Toby
AU - Rodrigues, Carina
AU - Asta, Federica
AU - Blaauwendraad, Sophia M.
AU - Håberg, Siri E.
AU - Halliday, Jane
AU - Harskamp-van Ginkel, Margreet W.
AU - He, Jian Rong
AU - Jaddoe, Vincent W.V.
AU - Lewis, Sharon
AU - Maher, Gillian M.
AU - Manios, Yannis
AU - McCarthy, Fergus P.
AU - Reiss, Irwin K.M.
AU - Rusconi, Franca
AU - Salika, Theodosia
AU - Tafflet, Muriel
AU - Qiu, Xiu
AU - Åsvold, Bjørn O.
AU - Burgner, David
AU - Chan, Jerry K.Y.
AU - Gagliardi, Luigi
AU - Gaillard, Romy
AU - Heude, Barbara
AU - Magnus, Maria C.
AU - Moschonis, George
AU - Murray, Deirdre
AU - Nelson, Scott M.
AU - Porta, Daniela
AU - Saffery, Richard
AU - Barros, Henrique
AU - Eriksson, Johan G.
AU - Vrijkotte, Tanja G.M.
AU - Lawlor, Deborah A.
N1 - Funding:
This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation
programme grant agreement No. 101021566 (ART-HEALTH) and No.
733206 (LifeCycle), the UK Medical Research Council (MC_UU_00011/6), the British Heart Foundation (CH/F/20/90003 and AA/18/1/34219)
and the Bristol National Institute of Health Research Biomedical
Research Centre. Cohort and author specific funding is provided in
Supplementary material online, Text S2.
Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2023/4/21
Y1 - 2023/4/21
N2 - Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age Methods Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance and results markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (−0.53 mmHg; 95% CI:−1.59 to 0.53), DBP (−0.24 mmHg; −0.83 to 0.35), or HR (0.02 beat/min; −0.91 to 0.94). Total cholesterol (2.59%; 0.10–5.07), HDL cholesterol (4.16%; 2.52–5.81), LDL cholesterol (4.95%; 0.47–9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
AB - Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age Methods Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance and results markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (−0.53 mmHg; 95% CI:−1.59 to 0.53), DBP (−0.24 mmHg; −0.83 to 0.35), or HR (0.02 beat/min; −0.91 to 0.94). Total cholesterol (2.59%; 0.10–5.07), HDL cholesterol (4.16%; 2.52–5.81), LDL cholesterol (4.95%; 0.47–9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
UR - http://www.scopus.com/inward/record.url?scp=85153412472&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehac726
DO - 10.1093/eurheartj/ehac726
M3 - Article
C2 - 36740401
AN - SCOPUS:85153412472
SN - 0195-668X
VL - 44
SP - 1464
EP - 1473
JO - European Heart Journal
JF - European Heart Journal
IS - 16
ER -
