Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on cognition in women with high familial risk of ovarian cancer: A cross-sectional study

Lara Terra, Philippe R. Lee Meeuw Kjoe, Joost A. Agelink van Rentergem, Maarten J. Beekman, Bernadette A.M. Heemskerk-Gerritsen, Marc van Beurden, Jeanine E. Roeters van Lennep, Helena C. van Doorn, Joanna A. de Hullu, Marian J.E. Mourits, Eleonora B.L. van Dorst, Constantijne H. Mom, Brigitte F.M. Slangen, Katja N. Gaarenstroom, Lizet E. van der Kolk, J. Margriet Collée, Marijke R. Wevers, Margreet G.E.M. Ausems, Klaartje van Engelen, Irma van de BeekLieke P.V. Berger, Christi J. van Asperen, Encarna B. Gomez Garcia, Angela H.E.M. Maas, Maartje J. Hooning, Elsken van der Wall, Flora E. van Leeuwen*, Sanne B. Schagen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Objective: To examine the effect of a premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design: A cross-sectional study with prospective follow-up, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population or Sample: 641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment. Methods: Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures: The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results: After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions: Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.

Original languageEnglish
Pages (from-to)968-977
Number of pages10
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume130
Issue number8
Early online date30 Jan 2023
DOIs
Publication statusPublished - Jul 2023

Bibliographical note

Funding Information:
The Dutch Cancer Society (KWF) granted funding for this project, registered under grant 10164. This study was peer‐reviewed by the Dutch Cancer Society and several patient panels before granting funding. The funding body had no role in the design of the study, collection, analysis, and interpretation of data or in writing the article.

Publisher Copyright: © 2023 John Wiley & Sons Ltd.

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