Long term follow-up of children with familial hypercholesterolemia and relatively normal LDL-cholesterol at diagnosis

Anja K. Johansen, Martin P. Bogsrud, Jeanine Roeters van Lennep, Ingunn Narverud, Gisle Langslet, Kjetil Retterstøl, Kirsten B. Holven*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Familial hypercholesterolemia (FH) is a genetic disorder with high low-density lipoprotein cholesterol (LDL-C) levels and high risk of cardiovascular disease. The long-term importance of carrying an FH mutation despite having relatively normal LDL-C levels in childhood is not known. We investigated the development of LDL-C levels and need of statin therapy in children with an FH mutation, with pretreatment LDL-C ≤ 4.1 mmol/L (~160 mg/dL), followed-up at lipid clinics in Oslo, Norway and Rotterdam, The Netherlands. Of 742 FH children, 109 (15%) had pretreatment LDL-C ≤ 4.1 mmol/L (~160 mg/dL) [mean (SD) 3.5 (0.5) mmol/L; (~130 (19) mg/dL)] measured at 11.8 (3.9) years of age [mean age (SD)]. After 8.2 (5.2) years [mean (SD)] of follow-up, 71.6% had started statin treatment. Therefore, all children carrying an FH mutation, independent of cholesterol levels, should receive follow-up at specialized lipid clinics for optimal and individualized treatment.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalJournal of Clinical Lipidology
Volume15
Issue number2
Early online date8 Feb 2021
DOIs
Publication statusPublished - 1 Mar 2021

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