Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: Five-year results of multiple invasive imaging modalities

Cihan Simsek, Antonios Karanasos, Michael Magro, Hector Garcia Garcia, Yoshinobu Onuma, Evelyn Regar, Eric Boersma, PWJC (Patrick) Serruys, Robert Jan van Geuns*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Abstract

Aims: Invasive imaging modalities have shown restoration of vasomotion, prevention of restenosis and, most importantly, increase in lumen area between six months and two years after first-generation everolimus-eluting bioresorbable vascular scaffold (Absorb BVS) implantation. Our aim was to assess whether these positive findings were sustained in the long term. Methods and results: Patients included in the ABSORB cohort A from the Thoraxcenter Rotterdam cohort underwent coronary catheterisation including angiography, intravascular ultrasound (IVUS), virtual histology, optical coherence tomography (OCT) and vasomotion testing at five years. Eight out of 16 patients underwent catheterisation and scaffold assessment with multiple imaging modalities. A trend towards an increase in minimum luminal diameter was observed between two and five years by angiography (1.95±0.37 mm vs. 2.14±0.38 mm; p=0.09). IVUS data showed an increase in mean lumen area at five years (6.96±1.13 mm2) compared to six months (6.17±0.74 mm2; p=0.06) and two years (6.56±1.16 mm2; p=0.12), primarily due to a persistent reduction in plaque area size between six months and five years (9.17±1.86 mm2 vs. 7.57±1.63 mm2; p=0.03). The necrotic core area was reduced at five years compared to post-procedural results. In OCT, an increase in mean and minimal luminal area was observed. Moreover, no scaffold struts could be identified and a smooth endoluminal lining was observed. The scaffolded coronary segment did not show signs of endothelial dysfunction with acetylcholine testing. Conclusions: At five years, the Absorb BVS is no longer discernible by any invasive imaging method and endothelial function is restored. Late luminal enlargement persists up to five years of follow-up without adaptive vessel remodelling.

Original languageEnglish
Pages (from-to)996-1003
Number of pages8
JournalEuroIntervention
Volume11
Issue number9
Early online dateOct 2014
DOIs
Publication statusPublished - Jan 2016

Bibliographical note

Publisher Copyright: © Europa Digital & Publishing 2016. All rights reserved.

Research programs

  • EMC COEUR-09

Fingerprint

Dive into the research topics of 'Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: Five-year results of multiple invasive imaging modalities'. Together they form a unique fingerprint.

Cite this