Long-term longitudinal changes in axial length in the Caucasian myopic and hyperopic population with a phakic intraocular lens

Zoraida S. Gaurisankar*, Gwyneth A. van Rijn, Geert W. Haasnoot, Virginie J.M. Verhoeven, Caroline C.W. Klaver, Gregorius P.M. Luyten, Jan Willem M. Beenakker

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Purpose: To determine the long-term longitudinal axial length changes in myopic and hyperopic adults with an iris-fixated phakic intraocular lens (pIOL). Methods: The medical records of patients aged ≥18 years with myopia or hyperopia who were treated with pIOL implantation between 1996 and 2011 for refractive correction with a minimum follow-up of 5 years after pIOL implantation were analyzed. The main outcome measure was change in ocular axial length over time. Results: 149 eyes of 149 myopic patients and 27 hyperopic eyes of 27 patients were included in this study. Mean patient age was 37.1 ± 10.4 years (35% male) in the myopic group and 39.4 ± 9.4 years (4% male) in the hyperopic group. The eyes of the myopic patients showed a significant mean increase in axial length of 0.45 ± 0.61 mm after a mean follow-up time of 144 ± 38 months (p < 0.001). In 26 eyes (17%), the axial length had increased by ≥1 mm. The mean annual axial length increase was 0.04 ± 0.06 mm. Axial elongation was associated with a higher degree of myopia (p < 0.001) and younger age (p = 0.02). The eyes of the hyperopic patients showed no change in axial length over time. Conclusions: Myopic eyes corrected with an iris-fixated pIOL show continuous increase in axial length at an adult age. Although this study is limited to subjects with a pIOL, this is the first time myopization in Caucasian adults has been reported in a large long-term longitudinal study.

Original languageEnglish
Pages (from-to)e562-e568
JournalActa Ophthalmologica
Issue number4
Early online date29 Oct 2020
Publication statusPublished - Jun 2021

Bibliographical note

Funding Information:
The authors thank Janette Symons for her assistance with medical writing. No conflicting relationship exists for any author.

Publisher Copyright:
© 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.


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