Long-term outcome after statin treatment in routine clinical practice: results from a prospective PCI cohort study

Jannet Eindhoven; Yoshinobu Onuma; Rohit Oemrawsingh; Joost Daemen; JWI van Nierop; Peter de Jaegere; Eric Boersma; PWJC (Patrick) Serruys; Ron van Domburg

doi:10.4244/EIJV7I12A222

Long-term outcome after statin treatment in routine clinical practice: results from a prospective PCI cohort study

Jannet Eindhoven, Yoshinobu Onuma, Rohit Oemrawsingh, Joost Daemen, JWI van Nierop, Peter de Jaegere, Eric Boersma, PWJC (Patrick) Serruys, Ron van Domburg

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Aims: We aim to investigate the association between different types of statins, in particular simvastatin and atorvastatin, and long-term mortality after percutaneous coronary intervention (PCI). Methods and results: Between 2000 and 2005, a prospective cohort was constituted of 5,647 patients who underwent PCI. Type and doses of statin use were collected after the PCI procedure. Survival status was obtained from municipal civil registries. The primary endpoint was all-cause mortality. Secondary endpoints were cardiac and cancer mortality. Median follow-up was 5.0 years (range three to nine years). During follow-up 738 patients (13.1%) died. In total, 4,970 patients (88%) were on statin Conclusions: In patients undergoing PCI the use of statins is associated with reduced mortality during prolonged follow-up. Patients using atorvastatin had a 23% lower mortality than those using simvastatin.

Original language	Undefined/Unknown
Pages (from-to)	1420-1427
Number of pages	8
Journal	EuroIntervention
Volume	7
Issue number	12
DOIs	https://doi.org/10.4244/EIJV7I12A222
Publication status	Published - 2012

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10.4244/EIJV7I12A222

http://hdl.handle.net/1765/74876

Cite this

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title = "Long-term outcome after statin treatment in routine clinical practice: results from a prospective PCI cohort study",

abstract = "Aims: We aim to investigate the association between different types of statins, in particular simvastatin and atorvastatin, and long-term mortality after percutaneous coronary intervention (PCI). Methods and results: Between 2000 and 2005, a prospective cohort was constituted of 5,647 patients who underwent PCI. Type and doses of statin use were collected after the PCI procedure. Survival status was obtained from municipal civil registries. The primary endpoint was all-cause mortality. Secondary endpoints were cardiac and cancer mortality. Median follow-up was 5.0 years (range three to nine years). During follow-up 738 patients (13.1%) died. In total, 4,970 patients (88%) were on statin Conclusions: In patients undergoing PCI the use of statins is associated with reduced mortality during prolonged follow-up. Patients using atorvastatin had a 23% lower mortality than those using simvastatin.",

author = "Jannet Eindhoven and Yoshinobu Onuma and Rohit Oemrawsingh and Joost Daemen and {van Nierop}, JWI and {de Jaegere}, Peter and Eric Boersma and Serruys, {PWJC (Patrick)} and {van Domburg}, Ron",

year = "2012",

doi = "10.4244/EIJV7I12A222",

language = "Undefined/Unknown",

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pages = "1420--1427",

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T1 - Long-term outcome after statin treatment in routine clinical practice: results from a prospective PCI cohort study

AU - Eindhoven, Jannet

AU - Onuma, Yoshinobu

AU - Oemrawsingh, Rohit

AU - Daemen, Joost

AU - van Nierop, JWI

AU - de Jaegere, Peter

AU - Boersma, Eric

AU - Serruys, PWJC (Patrick)

AU - van Domburg, Ron

PY - 2012

Y1 - 2012

N2 - Aims: We aim to investigate the association between different types of statins, in particular simvastatin and atorvastatin, and long-term mortality after percutaneous coronary intervention (PCI). Methods and results: Between 2000 and 2005, a prospective cohort was constituted of 5,647 patients who underwent PCI. Type and doses of statin use were collected after the PCI procedure. Survival status was obtained from municipal civil registries. The primary endpoint was all-cause mortality. Secondary endpoints were cardiac and cancer mortality. Median follow-up was 5.0 years (range three to nine years). During follow-up 738 patients (13.1%) died. In total, 4,970 patients (88%) were on statin Conclusions: In patients undergoing PCI the use of statins is associated with reduced mortality during prolonged follow-up. Patients using atorvastatin had a 23% lower mortality than those using simvastatin.

AB - Aims: We aim to investigate the association between different types of statins, in particular simvastatin and atorvastatin, and long-term mortality after percutaneous coronary intervention (PCI). Methods and results: Between 2000 and 2005, a prospective cohort was constituted of 5,647 patients who underwent PCI. Type and doses of statin use were collected after the PCI procedure. Survival status was obtained from municipal civil registries. The primary endpoint was all-cause mortality. Secondary endpoints were cardiac and cancer mortality. Median follow-up was 5.0 years (range three to nine years). During follow-up 738 patients (13.1%) died. In total, 4,970 patients (88%) were on statin Conclusions: In patients undergoing PCI the use of statins is associated with reduced mortality during prolonged follow-up. Patients using atorvastatin had a 23% lower mortality than those using simvastatin.

U2 - 10.4244/EIJV7I12A222

DO - 10.4244/EIJV7I12A222

M3 - Article

SN - 1774-024X

VL - 7

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JO - EuroIntervention

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