Long-term outcome of kidney transplantation in patients with a urinary conduit: A case-control study

Inez K.B. Slagt, Jan N.M. Ijzermans, Mustafa Alamyar, Paul C.M.S. Verhagen, Willem Weimar, Joke I. Roodnat, Türkan Terkivatan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Purpose: To study the short- and long-term outcomes of kidney transplantation in patients with a bladder augmentation or urinary diversion compared to patients with a kidney transplantation in a normal functional bladder. Patients and methods: Between January 2000 and March 2011, 13 patients received 16 grafts into a reconstructed urinary tract. We performed a retrospective case-control study and matched each patient to 4 controls for donor and recipient gender and year of transplantation. Results: Short- and long-term complications of kidney transplantation occurred in 12 patients, varying from urinary tract infections to medical hospitalization with or without surgical or radiological intervention. In 5 patients, a percutaneous nephrostomy (PCN) was placed followed by surgical re-intervention. In three patients, the grafts failed as a result of chronic rejection and were re-transplanted. There was no graft loss as a result of surgical complications or the reconstructed urinary tract. One-year patient and graft survival was 100 %. After five years, all patients were alive and seven of nine grafts (77.8 %) were functioning. Mean follow-up time was 4.3 years. Among the controls, 55 grafts were transplanted in 52 patients. Ten patients received a PCN. Five patients needed surgical re-intervention. In three patients, transplantectomy was performed for ongoing rejection. Three patients were re-transplanted. One patient had a failing graft 7.5 years post-transplantation and became dialysis dependent. Conclusion: Kidney transplantation in patients with a reconstructed urinary tract has an increased complication rate. Nevertheless, the long-term results are comparable to patients with a normal urinary bladder.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalInternational Urology and Nephrology
Volume45
Issue number2
DOIs
Publication statusPublished - Apr 2013

Research programs

  • EMC MM-03-49-01
  • EMC MM-04-39-05
  • EMC MM-04-47-07

Fingerprint

Dive into the research topics of 'Long-term outcome of kidney transplantation in patients with a urinary conduit: A case-control study'. Together they form a unique fingerprint.

Cite this