Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia

Lize Jiskoot; Jessica Panman; L (Lauren) van Asseldonk; Sanne Franzen; Lieke Meeter; Laura Donker Kaat; Emma van der Ende; Elise Dopper; Reinier Timman; Rick van Minkelen; J.C. van Swieten; E van den Berg; Janne Papma

doi:10.1007/s00415-018-8850-7

Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia

Lize Jiskoot, Jessica Panman, L (Lauren) van Asseldonk, Sanne Franzen, Lieke Meeter, Laura Donker Kaat, Emma van der Ende, Elise Dopper, Reinier Timman, Rick van Minkelen, J.C. van Swieten, E van den Berg, Janne Papma^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).

Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.

MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.

Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.

Original language	English
Pages (from-to)	1381-1392
Number of pages	12
Journal	Journal of Neurology
Volume	265
Issue number	6
Early online date	7 Apr 2018
DOIs	https://doi.org/10.1007/s00415-018-8850-7
Publication status	Published - Jun 2018

Research programs

EMC NIHES-04-58-01

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REPUB_105694-OA.pdfFinal published version, 1.33 MBLicence: CC BY

http://hdl.handle.net/1765/105694

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Jiskoot, L., Panman, J., van Asseldonk, L., Franzen, S., Meeter, L., Donker Kaat, L., van der Ende, E., Dopper, E., Timman, R., van Minkelen, R., van Swieten, J. C., van den Berg, E., & Papma, J. (2018). Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia. Journal of Neurology, 265(6), 1381-1392. https://doi.org/10.1007/s00415-018-8850-7

@article{10954d979cc74aecbbe27b691b8f76b7,

title = "Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia",

abstract = "We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.",

author = "Lize Jiskoot and Jessica Panman and {van Asseldonk}, {L (Lauren)} and Sanne Franzen and Lieke Meeter and {Donker Kaat}, Laura and {van der Ende}, Emma and Elise Dopper and Reinier Timman and {van Minkelen}, Rick and {van Swieten}, J.C. and {van den Berg}, E and Janne Papma",

year = "2018",

month = jun,

doi = "10.1007/s00415-018-8850-7",

language = "English",

volume = "265",

pages = "1381--1392",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "D. Steinkopff-Verlag",

number = "6",

}

Jiskoot, L, Panman, J, van Asseldonk, L, Franzen, S , Meeter, L , Donker Kaat, L, van der Ende, E, Dopper, E, Timman, R, van Minkelen, R , van Swieten, JC, van den Berg, E & Papma, J 2018, 'Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia', Journal of Neurology, vol. 265, no. 6, pp. 1381-1392. https://doi.org/10.1007/s00415-018-8850-7

TY - JOUR

T1 - Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia

AU - Jiskoot, Lize

AU - Panman, Jessica

AU - van Asseldonk, L (Lauren)

AU - Franzen, Sanne

AU - Meeter, Lieke

AU - Donker Kaat, Laura

AU - van der Ende, Emma

AU - Dopper, Elise

AU - Timman, Reinier

AU - van Minkelen, Rick

AU - van Swieten, J.C.

AU - van den Berg, E

AU - Papma, Janne

PY - 2018/6

Y1 - 2018/6

N2 - We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.

AB - We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.

U2 - 10.1007/s00415-018-8850-7

DO - 10.1007/s00415-018-8850-7

M3 - Article

C2 - 29627938

SN - 0340-5354

VL - 265

SP - 1381

EP - 1392

JO - Journal of Neurology

JF - Journal of Neurology

IS - 6

ER -

Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia

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