Longitudinal MRI study in schizophrenia patients and their healthy siblings

Rachel G.H. Brans, Neeltje E.M. Van Haren, G. Caroline M. Van Baal, Wouter G. Staal, Hugo G. Schnack, René S. Kahn, Hilleke E. Hulshoff Pol

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)


To investigate whether genetic and/or disease-related factors are involved in progressive structural brain changes in schizophrenia, magnetic resonance imaging scans with a 5-year scan interval were acquired in patients, their same-gender siblings and matched healthy controls. Structural equation modelling was applied to assess disease and familial effects. Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process.

Original languageEnglish
Pages (from-to)422-423
Number of pages2
JournalBritish Journal of Psychiatry
Issue number5
Publication statusPublished - Nov 2008
Externally publishedYes


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