TY - JOUR
T1 - Longitudinal MRI study in schizophrenia patients and their healthy siblings
AU - Brans, Rachel G.H.
AU - Van Haren, Neeltje E.M.
AU - Van Baal, G. Caroline M.
AU - Staal, Wouter G.
AU - Schnack, Hugo G.
AU - Kahn, René S.
AU - Hulshoff Pol, Hilleke E.
PY - 2008/11
Y1 - 2008/11
N2 - To investigate whether genetic and/or disease-related factors are involved in progressive structural brain changes in schizophrenia, magnetic resonance imaging scans with a 5-year scan interval were acquired in patients, their same-gender siblings and matched healthy controls. Structural equation modelling was applied to assess disease and familial effects. Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process.
AB - To investigate whether genetic and/or disease-related factors are involved in progressive structural brain changes in schizophrenia, magnetic resonance imaging scans with a 5-year scan interval were acquired in patients, their same-gender siblings and matched healthy controls. Structural equation modelling was applied to assess disease and familial effects. Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process.
UR - https://www.scopus.com/pages/publications/55949099579
U2 - 10.1192/bjp.bp.107.041467
DO - 10.1192/bjp.bp.107.041467
M3 - Article
C2 - 18978326
AN - SCOPUS:55949099579
SN - 0007-1250
VL - 193
SP - 422
EP - 423
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 5
ER -
